4 ms·

> AlphaFold's approach seems like a recipe for over-fitting. Doesn't the CASP competition use unknown structures, which would have defeated over-fitting?

• l33tman 5y ago
  It does. I'm not sure what the poster above is referring to.
• COGlory 5y ago
  No, because 3D folds are conserved. That means, short of one of the unknowns containing a novel fold (which they havent), theres always a possibility kf overfitting.