It's worth noting too that that 4% diff is equally distributed across the genome. Gain of function (or any other engineered pathogen) would be using CRISPR etc

It's worth noting too that that 4% diff is equally distributed across the genome. Gain of function (or any other engineered pathogen) would be using CRISPR etc to change just the few vital parts like the spike protein. Not going in and making 100 other random pointless edits for no reason.