4 ms·

Yeah, I don't think it's good to grab onto anything in particular. That being said, the risks with certain drugs are very low. Hydroxychloroquine has some seri

Yeah, I don't think it's good to grab onto anything in particular. That being said, the risks with certain drugs are very low. Hydroxychloroquine has some serious side effects and appear to marginally improve results, hence they revoked the EUA. If you want to dive into the data, I recommend: https://c19early.com/ https://c19early.com/ A lot of the papers are sub-par (so are the COVID-19 spread, symptomology, PCR tests, etc). Even the CDC PCR testing protocol (shown to be erring in Nov 2020) is having its EUA revoked: https://www.cdc.gov/csels/dls/locs/2021/07-21-2021-lab-alert-Changes_CDC_RT-PCR_SARS-CoV-2_Testing_1.html https://www.cdc.gov/csels/dls/locs/2021/07-21-2021-lab-alert...

bb88 5y ago
> Hydroxychloroquine has some serious side effects and appear to marginally improve results, hence they revoked the EUA. I agree. HCQ was neither safe, nor truly effective (though the NIH study showed no effectiveness even though the FDA left that question open when they revoked the EUA). If ivermectin were truly 90% effective as the original paper claimed, then it should be very easy to replicate it, at any sample size. (e.g. The effect of alcohol on humans can be seen on a sample size of one. HIV retroviral drug studies had 90% effectiveness, and could be quickly measured by the T-cell count in any infected person) Researchers are humans. I believe there's some kind of "heroic/hope bias" with covid studies that warrants that extra skeptical look. If ivermectin had marginally successful data, the authors (or one of them) might have "juiced" it up to make it more efficacious than it was. It doesn't make them evil, but it does make them untrustworthy. On the other hand, I also wasn't a doctor in an emergency room last year.
- OrvalWintermute 5y ago
  All strong antivirals are likely to have some side effects. Almost every medical intervention has effects, the most common of which is a lighter wallet. I support Remdesivir/Veklury which is a potent IV antiviral. Likewise, it has the following side effects Hypersensitivity Including Infusion-Related and Anaphylactic Reactions Hypersensitivity reactions, including infusion-related and anaphylactic reactions, have been observed during and following administration of VEKLURY. Signs and symptoms may include hypotension, hypertension, tachycardia, bradycardia, hypoxia, fever, dyspnea, wheezing, angioedema, rash, nausea, diaphoresis, and shivering. Slower infusion rates, with a maximum infusion time of up to 120 minutes, can be considered to potentially prevent these signs and symptoms. Monitor patients under close medical supervision for hypersensitivity reactions during and following administration of VEKLURY. If signs and symptoms of a clinically significant hypersensitivity reaction occur, immediately discontinue administration of VEKLURY and initiate appropriate treatment. The use of VEKLURY is contraindicated in patients with known hypersensitivity to VEKLURY or any components of the product Increased Risk of Transaminase Elevations Transaminase elevations have been observed in healthy volunteers who received 200 mg of VEKLURY followed by 100 mg doses up to 10 days; the transaminase elevations were mild (Grade 1) to moderate (Grade 2) in severity and resolved upon discontinuation of VEKLURY. Transaminase elevations have also been reported in patients with COVID-19 who received VEKLURY. Because transaminase elevations have been reported as a clinical feature of COVID-19, and the incidence was similar in patients receiving placebo versus VEKLURY in clinical trials of VEKLURY, discerning the contribution of VEKLURY to transaminase elevations in patients with COVID-19 can be challenging

bb88 5y ago

> Hydroxychloroquine has some serious side effects and appear to marginally improve results, hence they revoked the EUA. I agree. HCQ was neither safe, nor truly effective (though the NIH study showed no effectiveness even though the FDA left that question open when they revoked the EUA). If ivermectin were truly 90% effective as the original paper claimed, then it should be very easy to replicate it, at any sample size. (e.g. The effect of alcohol on humans can be seen on a sample size of one. HIV retroviral drug studies had 90% effectiveness, and could be quickly measured by the T-cell count in any infected person) Researchers are humans. I believe there's some kind of "heroic/hope bias" with covid studies that warrants that extra skeptical look. If ivermectin had marginally successful data, the authors (or one of them) might have "juiced" it up to make it more efficacious than it was. It doesn't make them evil, but it does make them untrustworthy. On the other hand, I also wasn't a doctor in an emergency room last year.

OrvalWintermute 5y ago
All strong antivirals are likely to have some side effects. Almost every medical intervention has effects, the most common of which is a lighter wallet. I support Remdesivir/Veklury which is a potent IV antiviral. Likewise, it has the following side effects Hypersensitivity Including Infusion-Related and Anaphylactic Reactions Hypersensitivity reactions, including infusion-related and anaphylactic reactions, have been observed during and following administration of VEKLURY. Signs and symptoms may include hypotension, hypertension, tachycardia, bradycardia, hypoxia, fever, dyspnea, wheezing, angioedema, rash, nausea, diaphoresis, and shivering. Slower infusion rates, with a maximum infusion time of up to 120 minutes, can be considered to potentially prevent these signs and symptoms. Monitor patients under close medical supervision for hypersensitivity reactions during and following administration of VEKLURY. If signs and symptoms of a clinically significant hypersensitivity reaction occur, immediately discontinue administration of VEKLURY and initiate appropriate treatment. The use of VEKLURY is contraindicated in patients with known hypersensitivity to VEKLURY or any components of the product Increased Risk of Transaminase Elevations Transaminase elevations have been observed in healthy volunteers who received 200 mg of VEKLURY followed by 100 mg doses up to 10 days; the transaminase elevations were mild (Grade 1) to moderate (Grade 2) in severity and resolved upon discontinuation of VEKLURY. Transaminase elevations have also been reported in patients with COVID-19 who received VEKLURY. Because transaminase elevations have been reported as a clinical feature of COVID-19, and the incidence was similar in patients receiving placebo versus VEKLURY in clinical trials of VEKLURY, discerning the contribution of VEKLURY to transaminase elevations in patients with COVID-19 can be challenging