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> For the longer schedule, the antibody levels dropped off between first and second dose, which included the loss of any neutralising effect against the Delta v
by mistermann 5y ago
> For the longer schedule, the antibody levels dropped off between first and second dose, which included the loss of any neutralising effect against the Delta variant. However, T cell responses were consistent, indicating they may contribute to important protection against Covid-19 during this time.
Does this suggest that ~8 weeks after the second dose one will still have protection from plain covid, but protection again Delta variants will be diminished?
- tgsovlerkhgsel 5y agoThe sentence you quoted refers to the period between first and second dose. My understanding is that "if you get exposed to the Delta variant on the day before the second dose, you won't have neutralizing antibodies". It does not make a statement about what happens after the second dose.
- mistermann 5y agoAgreed, but it is suggestive that this is within the realm of possibilities, no? Otherwise, something interesting would have to be happening where after the first shot you lose delta ~immunity in eight weeks, but after the second you ~do not?
- tgsovlerkhgsel 5y agoPossibilities sure, but IMO that doesn't translate to "likely". Other vaccines also give you only minimal or short protection after the first dose with long-lasting protection after the second (or third) one.