It's looking extremely iffy right now as to whether it's even possible to achieve herd immunity against the current variants through vaccination, which will set

It's looking extremely iffy right now as to whether it's even possible to achieve herd immunity against the current variants through vaccination, which will set up basically the perfect environment to select for vaccine escape globally: enough people vaccinated that it's a strong advantage, but the virus can still spread and infect more people in order to get a chance to adapt.