> I would expect them to result in a more specific immunity which is easier for the virus to circumvent, my mutating only its spike protein. This is not clear

> I would expect them to result in a more specific immunity which is easier for the virus to circumvent, my mutating only its spike protein. This is not clear at all - actually the opposite might be the case. Natural immunity focuses on a number of 'markers' that are more likely to change than the spike protein. As far as I know we don't know yet. Here is a comparison with other vaccines [1]. [1] https://twitter.com/ENirenberg/status/1412865782862725125 https://twitter.com/ENirenberg/status/1412865782862725125