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I feel like a 60% attack rate among fully vaccinated people in one outbreak is pretty chilling, though. Like I'm glad they didn't have severe illness but this n

I feel like a 60% attack rate among fully vaccinated people in one outbreak is pretty chilling, though. Like I'm glad they didn't have severe illness but this news is disappointing. Delta seems to heavily dominate in Singapore [0], and they don't seem to have Gamma at all. The outbreak in this article was Gamma. This study doesn't jive well with the in-vitro tests of vaccinated serum against gamma and the numbers we're seeing broadly though, so I'm still hopeful this is a fluke occurrence. 0. https://www.reuters.com/world/asia-pacific/singapore-finds-delta-most-prevalent-among-virus-variants-locally-2021-06-09/ https://www.reuters.com/world/asia-pacific/singapore-finds-d...

refurb 5y ago
I wouldn't read too much into the 50% being fully vaccinated. Front-line workers (both medical and retail) are most likely to be exposed versus someone unvaccinated. In addition, as vaccination rates go up, you'd expect to see more fully vaccinated people test positive since there are so few unvaccinated people. Not sure why I got downvoted - this is exactly what we expected - the vaccine protects against serious disease, not necessarily infection. We have some data showing that vaccinated people have a reduced risk of infection, but it's still a significant risk.
- sterlind 5y ago
  60% of the gold miners that were fully vaccinated at this jobsite got infected and became mild to moderately ill. that's why this is interesting - it's a case study of vaccine effectiveness among a bunch of people exposed to one variant in one place.
  - refurb 5y ago
    I got my wires crossed, I thought OP was talking about Singapore where ~50% of those infected were fully vaccinated. Yes, you are correct that the miners are a defined population, all exposed to one variant in one place. It would suggest that the Singapore numbers aren't skewed that much by front-line workers being vaccinated at a higher rate.
dv_dt 5y ago
The guinea study does list one possibility that the working conditions of the miners sharing machine cabs could have contributed to the case too.
tzs 5y ago
One thing to keep in mind is that they were miners at a mining camp. They were in close contact with each other much of the time. Vaccination lowers your chances of getting COVID when you get exposed, but even a low probability per exposure can be significant if you are getting exposed over and over and over again.
- ianai 5y ago
  At that point it’s probably best to move past talking about a vaccine as conveying a percentage of immunity in aggregate among the population and to discuss the biological processes more deeply. Ie it’s really making your immune system have some ability to abate an amount of viral load hopefully more than baseline prior to vaccination. But it seems clear that any biological system would have an upper limit to abatement. I wonder whether that’s much of a fleshed out area of study.
vmception 5y ago
“Attack rate” is “testing positive” None of the vaccines were to prevent that I don’t understand how this messaging was lost

refurb 5y ago

I wouldn't read too much into the 50% being fully vaccinated. Front-line workers (both medical and retail) are most likely to be exposed versus someone unvaccinated. In addition, as vaccination rates go up, you'd expect to see more fully vaccinated people test positive since there are so few unvaccinated people. Not sure why I got downvoted - this is exactly what we expected - the vaccine protects against serious disease, not necessarily infection. We have some data showing that vaccinated people have a reduced risk of infection, but it's still a significant risk.

sterlind 5y ago
60% of the gold miners that were fully vaccinated at this jobsite got infected and became mild to moderately ill. that's why this is interesting - it's a case study of vaccine effectiveness among a bunch of people exposed to one variant in one place.
- refurb 5y ago
  I got my wires crossed, I thought OP was talking about Singapore where ~50% of those infected were fully vaccinated. Yes, you are correct that the miners are a defined population, all exposed to one variant in one place. It would suggest that the Singapore numbers aren't skewed that much by front-line workers being vaccinated at a higher rate.

dv_dt 5y ago

The guinea study does list one possibility that the working conditions of the miners sharing machine cabs could have contributed to the case too.

tzs 5y ago

One thing to keep in mind is that they were miners at a mining camp. They were in close contact with each other much of the time. Vaccination lowers your chances of getting COVID when you get exposed, but even a low probability per exposure can be significant if you are getting exposed over and over and over again.

ianai 5y ago
At that point it’s probably best to move past talking about a vaccine as conveying a percentage of immunity in aggregate among the population and to discuss the biological processes more deeply. Ie it’s really making your immune system have some ability to abate an amount of viral load hopefully more than baseline prior to vaccination. But it seems clear that any biological system would have an upper limit to abatement. I wonder whether that’s much of a fleshed out area of study.

vmception 5y ago

“Attack rate” is “testing positive” None of the vaccines were to prevent that I don’t understand how this messaging was lost