The CB1 receptors actually shrink up and recede with long term use and the effects change with aging. For many long term smokers, this long term heavy use does

The CB1 receptors actually shrink up and recede with long term use and the effects change with aging. For many long term smokers, this long term heavy use does bring more anxiety. Stronger THC profiles with less CBN, CBG, or CBD in the flower being smoked, coupled with the terpene profiles present in the flower also have widely varying effects. Some smoke a kush strain that is heavy in caryophylene, myrcene, and/or linalool and feel a relaxing effect. For some, couch locking, sedative effects cause more anxiety. While still for others, sometimes lemony strains full of limonene and pinene causes more anxiety but for others the limonene gives one an energetic and uplifting buzz without the anxiety. It's also a psychoactive (THC) and so similar to hallucinogens, for some it's what anxieties are already in the head that amplifies anxiety once high. Unless you dive deep into the latest chemical/terpene profiles or live in a legal state you may not have heard that much of the type of high actually comes from a compound effect of the terpenes present and level of THC to CBD to CBG to CBN. Every single strain and plant to plant should be thought of as a concoction of sorts.