3 ms·

David Sinclair is an expert on this and has said otherwise. Clinical trials are expensive. To fund them you need billions of dollars. Pharmas won’t fund rese

David Sinclair is an expert on this and has said otherwise. Clinical trials are expensive. To fund them you need billions of dollars. Pharmas won’t fund research in anti-aging directly because it’s not considered a disease, can’t get FDA approval, and thus couldn’t be sold. So, yes, you need to find another route to approval, similar to metformin and rapamycin.

ska 5y ago
Pharma companies won't fund research because they don't consider the risk-reward tradeoff worthwhile compared to other options for their resources. Off label use in endemic, and it does give a path to play with some things clinically; however if you formed a company around this idea and could have been demonstrated to do it, you'll be pulled off the market so fast it will make your head spin. What you are really talking about is about funding the research that wont work, in the hopes that eventually you hit on something that does. If you do hit on that and can rigorously demonstrate it, market access will not be a problem.
ALittleLight 5y ago
One thing I've never understood, given that trials are so insanely expensive, is why healthcare companies with billions of dollars don't open up "offshore" research facilities to do trials in more lax jurisdictions. I've done none of the research, just imagining, but if you were to open up a compound in Somalia or somewhere, make the appropriate political contributions, would you really be bogged down with lots of red tape? Could you just experiment and iterate fast enough to develop convincing therapies cheaply and then bring them to mature markets?
- beardyw 5y ago
  So, experiment on poor black people? I think you are on the wrong forum.
  - ALittleLight 5y ago
    The necessary part is only that the prospective subjects aren't protected by strict regulatory regimes like in the United States. Somalia, as, essentially, a failed state, I assume, has lax medical regulations and is a possible candidate for experimentation. I think it's a bit racist for you to generalize my description of a poor and under regulated state, like Somalia, as being equal to "black people". Not all countries in Africa are like Somalia, you know. I suggest reading a bit more about Africa. I personally enjoy watching YouTube videos made by creators in different countries, African countries have a wide range. As Mark Twain said, "Travel is fatal to prejudice". Today, we can virtually "travel" with the click of a button. Not all black people are poor Somalis!
    - beardyw 5y ago
      I would suggest you read "Medical experimentation in Africa" https://en.m.wikipedia.org/wiki/Medical_experimentation_in_Africa https://en.m.wikipedia.org/wiki/Medical_experimentation_in_A...
- deegles 5y ago
  The assumption that needs to be true is that experiments without as much regulation are just as valuable as those that have it. I don't know either way though.

ska 5y ago

Pharma companies won't fund research because they don't consider the risk-reward tradeoff worthwhile compared to other options for their resources. Off label use in endemic, and it does give a path to play with some things clinically; however if you formed a company around this idea and could have been demonstrated to do it, you'll be pulled off the market so fast it will make your head spin. What you are really talking about is about funding the research that wont work, in the hopes that eventually you hit on something that does. If you do hit on that and can rigorously demonstrate it, market access will not be a problem.

ALittleLight 5y ago

One thing I've never understood, given that trials are so insanely expensive, is why healthcare companies with billions of dollars don't open up "offshore" research facilities to do trials in more lax jurisdictions. I've done none of the research, just imagining, but if you were to open up a compound in Somalia or somewhere, make the appropriate political contributions, would you really be bogged down with lots of red tape? Could you just experiment and iterate fast enough to develop convincing therapies cheaply and then bring them to mature markets?

beardyw 5y ago
So, experiment on poor black people? I think you are on the wrong forum.
- ALittleLight 5y ago
  The necessary part is only that the prospective subjects aren't protected by strict regulatory regimes like in the United States. Somalia, as, essentially, a failed state, I assume, has lax medical regulations and is a possible candidate for experimentation. I think it's a bit racist for you to generalize my description of a poor and under regulated state, like Somalia, as being equal to "black people". Not all countries in Africa are like Somalia, you know. I suggest reading a bit more about Africa. I personally enjoy watching YouTube videos made by creators in different countries, African countries have a wide range. As Mark Twain said, "Travel is fatal to prejudice". Today, we can virtually "travel" with the click of a button. Not all black people are poor Somalis!
  - beardyw 5y ago
    I would suggest you read "Medical experimentation in Africa" https://en.m.wikipedia.org/wiki/Medical_experimentation_in_Africa https://en.m.wikipedia.org/wiki/Medical_experimentation_in_A...
deegles 5y ago
The assumption that needs to be true is that experiments without as much regulation are just as valuable as those that have it. I don't know either way though.