5 ms·

There are a lot of DIYers experimenting with senolytics and Rapamycin therapies for longevity. I expect that in the next 10 years or so evidence will be clear

There are a lot of DIYers experimenting with senolytics and Rapamycin therapies for longevity. I expect that in the next 10 years or so evidence will be clear that at least some of these therapies work. It will be undeniable as more and more people start to hit their 80s, 90s, and beyond in very good health. I'm in my 30s so not in need yet but I'm keeping a close eye on the science. For example, this clinical trial [0] is studying the safety of various dosing schedules of Rapamycin, and a planned followup study will use the safest dose with a larger group and longer timeline. [0] https://www.lifespan.io/campaigns/pearl-participatory-evaluation-of-aging-with-rapamycin-for-longevity/ https://www.lifespan.io/campaigns/pearl-participatory-evalua... edit: fine, maybe more than 10 years but within my lifetime :)

p1esk 5y ago
the next 10 years or so evidence will be clear that at least some of these therapies work. I think you forgot an extra zero
- deleted 5y ago
  [deleted]
ska 5y ago
> I expect that in the next 10 years or so evidence will be clear that at least some of these therapies work. It's an interesting area, and at least some empirically useful work is being done, but both the expectation and the timeline here seem pretty ambitious.
bserge 5y ago
They're not DIYers when using a prescription drug. Something inaccessible to the majority of the population. Can't wait for a time when trying to delay your death requires serious justification and approval from some asshole whose only authority comes from 5+ years of overpriced formal education.
- ixacto 5y ago
  Sortof. But the assholes do know a bit about science, and are taking an arguably conservative view on pharmacological interventions in the treatment of aging to prevent possible problems. For example this trial: Targeting the Biology of Aging. Ushering a New Era of Interventions. The official web resource of the TAME Trial, managed by the American Federation for Aging Research. they are not saying that taking metformin slows aging, merely that it delays development of chronic illnesses. What we should be asking is if metformin is actually slowing down the biological aging process. https://www.afar.org/tame-trial https://www.afar.org/tame-trial
maroonblazer 5y ago
I'm skeptical of miracle cures. The increases we've seen in life expectancy over the last 100+ years has more to do with eliminating low-hanging fruit - e.g. smoking, vaccines, eliminating infection, diagnostic technologies and treatments, etc. I think we'll continue to make incremental gains via this approach such that avg life expectancy inches up by single digits for the foreseeable future.

p1esk 5y ago

the next 10 years or so evidence will be clear that at least some of these therapies work. I think you forgot an extra zero

deleted 5y ago
[deleted]

ska 5y ago

> I expect that in the next 10 years or so evidence will be clear that at least some of these therapies work. It's an interesting area, and at least some empirically useful work is being done, but both the expectation and the timeline here seem pretty ambitious.

bserge 5y ago

They're not DIYers when using a prescription drug. Something inaccessible to the majority of the population. Can't wait for a time when trying to delay your death requires serious justification and approval from some asshole whose only authority comes from 5+ years of overpriced formal education.

ixacto 5y ago
Sortof. But the assholes do know a bit about science, and are taking an arguably conservative view on pharmacological interventions in the treatment of aging to prevent possible problems. For example this trial: Targeting the Biology of Aging. Ushering a New Era of Interventions. The official web resource of the TAME Trial, managed by the American Federation for Aging Research. they are not saying that taking metformin slows aging, merely that it delays development of chronic illnesses. What we should be asking is if metformin is actually slowing down the biological aging process. https://www.afar.org/tame-trial https://www.afar.org/tame-trial

maroonblazer 5y ago

I'm skeptical of miracle cures. The increases we've seen in life expectancy over the last 100+ years has more to do with eliminating low-hanging fruit - e.g. smoking, vaccines, eliminating infection, diagnostic technologies and treatments, etc. I think we'll continue to make incremental gains via this approach such that avg life expectancy inches up by single digits for the foreseeable future.