3 ms·

I've seen someone have a textbook psychotic break while consuming a lot of cannabis. Radio was sending them secret messages, coworkers were government spies, be

I've seen someone have a textbook psychotic break while consuming a lot of cannabis. Radio was sending them secret messages, coworkers were government spies, believed they were Jesus (and normally they'd been a confirmed atheist). As soon as the cannabis consumption stopped, the psychosis stopped. They started smoking again, symptoms came back. I'd also done some googling to try to understand why some people have panic attacks, and there seems to be a link to cannabis and hypoglycemia for some people. Hypoglycemia can cause: psychosis and panic attacks.

ajkjk 5y ago
I've known a few people that this happens to. Not sure it's the same as long-term schizophrenia but there's definitely similarities.
code_duck 5y ago
It would be interesting to know more about the hypoglycemia link. I contracted type one diabetes as an adult, somehow, and was hesitant to try anything for the first time after that including alcohol or cannabis. I wear a continuous glucose monitor and as far as I can tell, cannabis has no effect on my blood glucose.
- mullingitover 5y ago
  There's this study published in Diabetes Care[1], "Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study". > RESULTS Compared with placebo, THCV significantly decreased fasting plasma glucose (estimated treatment difference [ETD] = −1.2 mmol/L; P < 0.05) and improved pancreatic β-cell function (HOMA2 β-cell function [ETD = −44.51 points; P < 0.01]), adiponectin (ETD = −5.9 × 106 pg/mL; P < 0.01), and apolipoprotein A (ETD = −6.02 μmol/L; P < 0.05), although plasma HDL was unaffected. Compared with baseline (but not placebo), CBD decreased resistin (−898 pg/ml; P < 0.05) and increased glucose-dependent insulinotropic peptide (21.9 pg/ml; P < 0.05). None of the combination treatments had a significant impact on end points. CBD and THCV were well tolerated. [1] https://care.diabetesjournals.org/content/39/10/1777.long https://care.diabetesjournals.org/content/39/10/1777.long
  - code_duck 5y ago
    In the case of type 2 diabetes patients, reducing fasting plasma glucose is exactly what you would want to do since chronic hyperglycemia is the major issue in that condition. It’s not clear if it would work the same for type 1 or non-diabetic people.
webinvest 5y ago
It could be a stimulant drug and situational interaction
meowface 5y ago
Interestingly, it's sometimes recommended to quickly consume a lot of highly sugary foods if you feel panic/anxiety from cannabis. (And I've found that this has worked for me. Plus you get the bonus of them tasting especially delicious.)

ajkjk 5y ago

I've known a few people that this happens to. Not sure it's the same as long-term schizophrenia but there's definitely similarities.

code_duck 5y ago

It would be interesting to know more about the hypoglycemia link. I contracted type one diabetes as an adult, somehow, and was hesitant to try anything for the first time after that including alcohol or cannabis. I wear a continuous glucose monitor and as far as I can tell, cannabis has no effect on my blood glucose.

mullingitover 5y ago
There's this study published in Diabetes Care[1], "Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study". > RESULTS Compared with placebo, THCV significantly decreased fasting plasma glucose (estimated treatment difference [ETD] = −1.2 mmol/L; P < 0.05) and improved pancreatic β-cell function (HOMA2 β-cell function [ETD = −44.51 points; P < 0.01]), adiponectin (ETD = −5.9 × 106 pg/mL; P < 0.01), and apolipoprotein A (ETD = −6.02 μmol/L; P < 0.05), although plasma HDL was unaffected. Compared with baseline (but not placebo), CBD decreased resistin (−898 pg/ml; P < 0.05) and increased glucose-dependent insulinotropic peptide (21.9 pg/ml; P < 0.05). None of the combination treatments had a significant impact on end points. CBD and THCV were well tolerated. [1] https://care.diabetesjournals.org/content/39/10/1777.long https://care.diabetesjournals.org/content/39/10/1777.long
- code_duck 5y ago
  In the case of type 2 diabetes patients, reducing fasting plasma glucose is exactly what you would want to do since chronic hyperglycemia is the major issue in that condition. It’s not clear if it would work the same for type 1 or non-diabetic people.

webinvest 5y ago

It could be a stimulant drug and situational interaction

meowface 5y ago

Interestingly, it's sometimes recommended to quickly consume a lot of highly sugary foods if you feel panic/anxiety from cannabis. (And I've found that this has worked for me. Plus you get the bonus of them tasting especially delicious.)