4 ms·

https://cen.acs.org/pharmaceuticals/drug-delivery/Without-lipid-shells-mRNA-vaccines/99/i8 https://cen.acs.org/pharmaceuticals/drug-delivery/Without-li... http

• adrianN 5y ago
  Thanks! So the main concern seems to be autoimmune disease? > Overall, the robust inflammatory milieu induced by LNPs, combined with presentation of the vaccine-derived peptides/protein outside of antigen-presenting cells, might cause tissue damage and exacerbate side effects. Since self-antigen presentation in an inflammatory environment has been linked to autoimmune disease development (Charles A Janeway et al., 2001), this merits further investigation, albeit not detected here. Because short term inflammation is, as far as I know, not a big deal and somewhat desirable for vaccinations? It is my understanding that we intentionally mix in inflammatory substances ("adjuvants") with normal vaccines to kick the immune system into action?