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Tell HN: Perl + Lion got you down? Have no fear.
Immediately after doing a clean install of Lion yesterday, I sat down to work getting my environment back up to speed.
tl;dr - Homebrew, check (few formulas are tricky, but basically good); rvm, check (haven't tried to build 1.8.7, which was a problem but maybe no longer); Perlbrew + newer Perls, boom.
There is an issue with /usr/bin/nm and Perl's configuration and OS hints scripts. After some discussion, it turned out that the p5-porters were already on it (in blead-perl) and a quick patch has been made to Devel::PatchPerl.
See here for more gory details of what to do: http://www.perlbrew.pl/FixLion.html
(A big thanks to Gugod and Bingos!)