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Do we know why the blood glucose gets too high? From what I understand our cells reduce the number of insulin receptors which leads them to absorb less glucose

by rdedev 5y ago

Do we know why the blood glucose gets too high? From what I understand our cells reduce the number of insulin receptors which leads them to absorb less glucose and hence lead to increased blood glucose. But the reason for this insulin resistance is still sort of up for debate. Atleast this is what I understood.

mnw21cam 5y ago
There are a few theories out there, and the truth is probably a mixture of them along with some we don't know about. However, firstly, type 2 diabetes starts out with no significant increase in blood glucose. The reason for this is that the body is very good at self-regulating (homeostasis), so it just produces a bit more insulin to keep glucose levels about right. This happens in the pre-diabetes stage. The insulin tells the fat cells to convert glucose into fat and store it, which causes people to put on weight. Type 2 diabetes should be viewed as a disease of too much insulin required, rather than too much glucose present. Yes, there ends up being too much glucose, but the primary problem is that you are giving the body too much energy to store, and it needs to produce too much insulin in order to do that. This leads into one reason for insulin resistance - the fat cells that are already full need a higher and higher level of insulin to persuade them to keep that energy stored there. Adding more insulin gets them to cram more in, but there is a limit to how much they can. Another possible reason for insulin resistance is constant high levels of insulin in the blood. Like a drug which you become resistant to if you are constantly taking it, your cells probably get resistant to the insulin. Insulin is secreted in response to high blood glucose and food intake. So there are two things that can cause a constant high level of insulin. The first is if fat cells are full, and they need a high insulin level to stop them dumping the stored energy back into the blood in the form of glucose. The second is if you're constantly snacking. For that reason, it is a real benefit to have a decent long stretch of the day when you don't eat anything. It used to be quite normal to have an evening meal at 6:30pm, and then not eat anything until breakfast the next morning, which gives the body a nice 12-ish-hour session each day of low insulin levels that allow resistance to recover. It's one reason why the 5-2 diet (where you eat normally for five days and then fast or severely diet for two days, every week) is successful.
Projectiboga 5y ago
Basically with Type 2 diabetes it is runaway inflammation with a genetic makeup that causes the insulin receptors to get less efficient. Insulin is the key that allows the glucose to get transferred into a cell. Once the body is starving for carbohydrates it begins a process to break down fats and even protein into an energy source. This produces toxins, ketones. That is a brief overview of the biggest factors. To prevent, or reverse this downward spiral, eating better will help and there is a simple life hack. Melatonin upregulates insulin receptors, this works for everyone not just already diagnosed diabetics. With Type 1 autoimmune diabetes melatonin can reduce insulin requirements but won't eliminate the need for insulin. With Type 2 and with prediabetes melatonin along with minding your diet can have a dramatic effect. Increasing the ratio of unsaturated fats (health plant oils not palm oil) like olive oil and increasing plant based protein sources like eating beans, peas or lentils for some of your meals will help reduce the risk of diabetic complications. Another hack if you go with any amount of a plant based diet is to eat raw miso from the tub or to carefully make it into broth with water under 130 fahrenheit. Miso is full of microbes that make plant protein more digestible and useable by the body than any other source.
- bpizzi 5y ago
  > Once the body is starving for carbohydrates it begins a process to break down fats and even protein into an energy source. This produces toxins, ketones. You may want to read some (hopefully) unbiased information on that subject : https://en.wikipedia.org/wiki/Ketone_bodies https://en.wikipedia.org/wiki/Ketone_bodies https://en.wikipedia.org/wiki/Ketogenesis https://en.wikipedia.org/wiki/Ketogenesis For example: > Both [two of the three types of ketone bodies] are 4-carbon molecules that can readily be converted back into acetyl-CoA [which can directly fuel the krebs cycle] by most tissues of the body, with the notable exception of the liver. Which is not really matching the definition of 'toxins'. In my mind, saying that ketone bodies are toxins could be suggested in the fact that ketoacidosis is a real threat when a metabolism is affected by T1. But, again, T1 is not T2, and it's not the condition of a healthy metabolism, which is fully capable of handling ketone bodies, even thriving on it (glucose is fine, too, I'm not trying to sell that line).
  - 5y ago

by rdedev 5y ago

mnw21cam 5y ago

There are a few theories out there, and the truth is probably a mixture of them along with some we don't know about. However, firstly, type 2 diabetes starts out with no significant increase in blood glucose. The reason for this is that the body is very good at self-regulating (homeostasis), so it just produces a bit more insulin to keep glucose levels about right. This happens in the pre-diabetes stage. The insulin tells the fat cells to convert glucose into fat and store it, which causes people to put on weight. Type 2 diabetes should be viewed as a disease of too much insulin required, rather than too much glucose present. Yes, there ends up being too much glucose, but the primary problem is that you are giving the body too much energy to store, and it needs to produce too much insulin in order to do that. This leads into one reason for insulin resistance - the fat cells that are already full need a higher and higher level of insulin to persuade them to keep that energy stored there. Adding more insulin gets them to cram more in, but there is a limit to how much they can. Another possible reason for insulin resistance is constant high levels of insulin in the blood. Like a drug which you become resistant to if you are constantly taking it, your cells probably get resistant to the insulin. Insulin is secreted in response to high blood glucose and food intake. So there are two things that can cause a constant high level of insulin. The first is if fat cells are full, and they need a high insulin level to stop them dumping the stored energy back into the blood in the form of glucose. The second is if you're constantly snacking. For that reason, it is a real benefit to have a decent long stretch of the day when you don't eat anything. It used to be quite normal to have an evening meal at 6:30pm, and then not eat anything until breakfast the next morning, which gives the body a nice 12-ish-hour session each day of low insulin levels that allow resistance to recover. It's one reason why the 5-2 diet (where you eat normally for five days and then fast or severely diet for two days, every week) is successful.

Projectiboga 5y ago

Basically with Type 2 diabetes it is runaway inflammation with a genetic makeup that causes the insulin receptors to get less efficient. Insulin is the key that allows the glucose to get transferred into a cell. Once the body is starving for carbohydrates it begins a process to break down fats and even protein into an energy source. This produces toxins, ketones. That is a brief overview of the biggest factors. To prevent, or reverse this downward spiral, eating better will help and there is a simple life hack. Melatonin upregulates insulin receptors, this works for everyone not just already diagnosed diabetics. With Type 1 autoimmune diabetes melatonin can reduce insulin requirements but won't eliminate the need for insulin. With Type 2 and with prediabetes melatonin along with minding your diet can have a dramatic effect. Increasing the ratio of unsaturated fats (health plant oils not palm oil) like olive oil and increasing plant based protein sources like eating beans, peas or lentils for some of your meals will help reduce the risk of diabetic complications. Another hack if you go with any amount of a plant based diet is to eat raw miso from the tub or to carefully make it into broth with water under 130 fahrenheit. Miso is full of microbes that make plant protein more digestible and useable by the body than any other source.

bpizzi 5y ago
> Once the body is starving for carbohydrates it begins a process to break down fats and even protein into an energy source. This produces toxins, ketones. You may want to read some (hopefully) unbiased information on that subject : https://en.wikipedia.org/wiki/Ketone_bodies https://en.wikipedia.org/wiki/Ketone_bodies https://en.wikipedia.org/wiki/Ketogenesis https://en.wikipedia.org/wiki/Ketogenesis For example: > Both [two of the three types of ketone bodies] are 4-carbon molecules that can readily be converted back into acetyl-CoA [which can directly fuel the krebs cycle] by most tissues of the body, with the notable exception of the liver. Which is not really matching the definition of 'toxins'. In my mind, saying that ketone bodies are toxins could be suggested in the fact that ketoacidosis is a real threat when a metabolism is affected by T1. But, again, T1 is not T2, and it's not the condition of a healthy metabolism, which is fully capable of handling ketone bodies, even thriving on it (glucose is fine, too, I'm not trying to sell that line).
- 5y ago