This is for relatively high concentrations of CBD in isolation. Notably, adding human serum greatly diminishes the effects because the CBD is highly protein bou

This is for relatively high concentrations of CBD in isolation. Notably, adding human serum greatly diminishes the effects because the CBD is highly protein bound. > In line with previous reports, addition of 50% human serum to the assay media abrogated antibacterial activity in our tests (MRSA MIC >256 μg mL−1). This decreased activity is likely due to low levels of free CBD as a result of CBD’s previously reported high levels of protein binding. One publication describes CBD as 86–90% bound in human plasma25, though THC and other cannabinoids have even higher levels of 95–99% binding, primarily to lipoproteins26,27, and the Epidiolex FDA filing indicates >94% protein binding for CBD and its metabolites (with up to >99% depending on method used)28 The concentrations required for efficacy are also generally much higher than typical antibiotics. This essentially has zero relevance to humans consuming CBD. It's interesting because researchers could potentially use the CBD structure as a hint for developing new antibiotics.