There's two parts to this. The first is the broad question of "how will any app (regardless of the technology) saturate that much hardware", and to that I simp

There's two parts to this. The first is the broad question of "how will any app (regardless of the technology) saturate that much hardware", and to that I simply say it won't; it will saturate -something- first (with enough load), be it RAM, CPU, network I/O, disk I/O, etc, which will limit utilization of the rest. If this was your own datacenter you might try and "right size" to that, to try and have as little unused hardware capacity as possible, but in the cloud you don't (can't) do that. The second is maybe more what you're trying to ask, which is given that node is single threaded, you would only be using one core, and that would implicitly also limit how much of the other resources you can use. To that, you'd use something like PM2, a node native utility which essentially spins up multiple instances of your app locally, and load balances across them, or the cluster lib, a less feature rich solution to the same problem, but supplied as part of the standard library.