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Since this is the first cannabis topic I've seen on HN, I have lots of questions/ideas/problems I want to share. I'm going to post them in no particular order.
by deregulateMed 5y ago
Since this is the first cannabis topic I've seen on HN, I have lots of questions/ideas/problems I want to share. I'm going to post them in no particular order. Maybe someone has a solution
>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious.
>Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use?
>Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time.
>Is there a solution to munchies?
>Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem.
> Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names.
>If my focus is better on weed, is there something else I can do for focus that isn't drug related?
- bobiny 5y ago>Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. -vaporizing and less potent weed >Is there a solution to munchies? -from my experience they go away at some point. You still have the from time to time but much less often. >If my focus is better on weed, is there something else I can do for focus that isn't drug related? -meditation
- hrh 5y ago>I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious. This is not something I've solved but are you consuming large amounts? I can stay high for months on end, using every hour and while it's not going to hit me like the first hit, I say up. I'd like to be more regular in consumption (every 4 hours), but your guess is as good as mine >Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use? Is investing in any US-based company encouraging war? Is investing in any company that uses Chinese production promoting slavery? Caffeine is a drug. We take lots of drugs. We are in the infancy of understanding many of them because we're young and because we've been prudes. I'd rather see companies and people I'd trust pushing and producing drug products of any kind rather than abusers. You can see this happening in the hemp adjacent markets - lots and lots of shady fly by night companies have popped up but slowly the good ones are rising to the top. 3chi, for example is a popular and I think solid d8 company. But as I told my dad, every single person that was selling pot on the street is trying to get into the drug business and has been for more than a decade...good luck picking winners. >Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem. > Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names. This is my main concern (and lung damange). I do notice lapses in short-term memory (though I am high when this happens, I haven't noticed a huge drop). The literature sugests it's relatively small over decades IIRC. Willie Nelson and Snoop (sample of 2) are doing ok. >If my focus is better on weed, is there something else I can do for focus that isn't drug related? Get off HN. ;)
- deleted 5y ago[deleted]
- buu700 5y agoCaffeine is a drug. We take lots of drugs. We are in the infancy of understanding many of them because we're young and because we've been prudes. Personally, I don't think it's going to be all that long before society's mental model of cannabis is fully turned on it's head from where it was 20 years ago. The dose makes the poison (or drug), after all. Fundamentally, I see cannabinoids as less like alcohol, and more like a potential new category of vitamin. As we continue to learn more about the endocannabinoid system and build up increasing experimental evidence tying common maladies to endocannabinoid deficiencies, I see cannabinoid supplements eventually becoming as commonplace as e.g. B-complex and incorporated into mainstream multivitamins. Going back to GP's questions: Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. Tinctures/oils. Sublingual absorption is the next best thing to pulmonary absorption in terms of efficiency, but it won't cause long-term damage as inhaling hot ashes and gases might, and it'll allow you to measure the dose down to the mg. Is there a solution to munchies? Speaking for myself, I've been microdosing 200mg of Sunsoil full-spectrum CBD oil and 50mg of 3Chi delta-8-THC oil first thing in the morning and before bed since around the end of April. This helps with both my sleep quality/consistency and preventing semi-regular headaches that had been causing an unhealthy reliance on NSAIDs. It doesn't cause a high or any noticeable psychoactive effect. However, rather than "munchies", it's actually significantly reduced my appetite. Without any other deliberate change to my routine, such as calorie counting/restriction, I've dropped from 210 to 186 over the past 2.5 months with no perceptible loss in muscle strength or mass, and so far see no signs of the trend stopping before I reach my goal BF%. (I use the term "deliberate" because, although I am currently only eating one meal per day around lunch - dinner time, it isn't an intentional IF/OMAD schedule; it's just the current limit of my appetite.) That being said, I can't definitively attribute this effect to a particular compound. It could be the delta8, it could be the CBD, it could be a different cannabinoid, it could be the interactions between some or all of them, it could be the 200 calories of MCT oil that I'm now ingesting each day (on top of what I was already taking separately pre-workout), and/or it could be the interactions of any or all of the above with the fact that I've been keto for over nine years. YMMV.
- yesenadam 5y agoYou must've missed this AskHN from yesterday https://news.ycombinator.com/item?id=27856934 https://news.ycombinator.com/item?id=27856934 I think you might find answers to half your questions there. And please ask your own AskHN with your questions, it's better than asking a lot of questions in a comment like this—AskHNs disappear off the radar a lot slower than news stories like this, and you probably will get a lot more answers.
- mallomarmeasle 5y agoMedicinal Chemist (and former cannabis consumer) here. >I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance... Interestingly, I used to notice that once I became tolerant to one strain, over a couple weeks, switching to another strain could at least partially alleviate it. This to me is fascinating. Psychoactive effects of cannabinoids are thought to be mediated by the CB1 receptor. Cannabis strains can vary strongly in their perceived effects. Are there subtypes of the CB1 receptor differentially activated by the various cannabinoids present at different levels in the strains? For instance CB1a and CB1b? I do not think this is known. >If my focus is better on weed, is there something else I can do for focus that isn't drug related? This sounds like a line from John Stewart in some stoner movie
- irthomasthomas 5y ago"In 1998, Professors Raphael Mechoulam and Shimon Ben-Shabat posited that the endocannabinoid system demonstrated an “entourage effect” in which a variety of “inactive” metabolites and closely related molecules markedly increased the activity of the primary endogenous cannabinoids, anandamide and 2-arachidonoylglycerol" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334252/#:~:text=In%201998%2C%20Professors%20Raphael%20Mechoulam,cannabinoids%2C%20anandamide%20and%202%2Darachidonoylglycerol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334252/#:~:tex...
- snarfy 5y agoHere is my anecdata after being a regular user for 30+ years. >I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious. You have to limit your intake. It's really easy to over do it with pipes and bongs. You'll end up getting 10x as much as you need and blow your tolerance. >Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use? No less ethical than investing in entertainment. >Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. The best way is to use a vape pen and oil. Set a low wattage and then count x seconds while hitting it. >Is there a solution to munchies? Smoke less. It's a symptom of smoking too much. You feel more sober after eating. The hunger is your brain trying to get sober. >Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem. Not fortune 500 but I've known multiple cancer patients where it was not as stigmatized. > Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names. Weed messes with your memory pretty significantly. If you were high when the memories formed you will struggle to remember them when not high. I learned how to play guitar while high and can't really play if I'm not. I'd need to spend a lot of time relearning how to play sober. >If my focus is better on weed, is there something else I can do for focus that isn't drug related? Competitive gaming. Join a clan.
- atatatat 5y agoOP needs a loose leaf vaporizer, like the Pax.
- vincentmarle 5y ago> Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. I’m not sure if this is still considered microdose, but 5mg sativa edibles hit the sweet spot for me in terms of being productive for several hours and not being too high. YMMV
- arcturus17 5y agoI’ve also found edibles to be the best way to control dosing. Though in my case I’ve never found cannabis to be a productive drug - I mini-dosed for leisure only and to great effect.
- neom 5y agoSmoked weed every day for 10 years. >I like weed as a productive drug, it's stronger than caffeine for me, but I develop tolerance and addiction quickly. Any solution to the tolerance problem? Quitting/breaks is obvious. Switch strains frequently, try to find stuff far from the other. >Is investing in weed stocks encouraging drug addiction/use? Is it ethical to promote drug use? No, but also investing in weed stocks are probably not the best stocks you could invest in - that said: Invest in what you know! >Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. Yes, but you'll have to take a huge long break to get your tolerance back down. Then make tea: https://www.thrillist.com/eat/nation/how-to-make-cannabis-tea-recipe https://www.thrillist.com/eat/nation/how-to-make-cannabis-te... >Is there a solution to munchies? Switch strains - tends to be more common in Indicas with a higher than normal CBD (or if you're into more "creative" solutions, low dose adderall with it, seems to balance out well in strains that cause munchies.) >Has anyone been able to convince a fortune 500 company that they need(medical) marijuana for work? As mentioned I'm significantly more focused, but I don't like the social stigma. I already have the job, it's purely a cultural/social problem. If you have a Drs note, there isn't much they can do. > Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names. I've read reports of this, I've anecdotally heard people say that - It's never been a problem for me (but aging certainly has) >If my focus is better on weed, is there something else I can do for focus that isn't drug related? Diaphragmatic breathing for 5 minutes when you find your mind wandering.
- pmoriarty 5y ago"If you have a Drs note, there isn't much they can do." Many jobs require passing drug tests as a condition of employment. It would be interesting to hear if anyone has challenged such tests by arguing their cannabis use was a medical necessity.
- GravitasFailure 5y agoI worked with two different people that tried that. First guy crashed a forklift and was told he couldn't operate heavy machinery while taking any kind of depressant medication, and the second one was an armed security guard who tried explaining that his paranoid behavior was from switching cannabis strains. Under federal law it's a felony to own or possess a firearm while a user of cannabis, and the court cases so far have not been friendly to medical users.
- erdos4d 5y agoI know this sounds bad, but the addiction aspect can be mitigated by living life and being in positions where you need to quit smoking numerous times for whatever reasons. You learn how to master the desire. With that said, I also agree with you that it is a wonderful productivity drug. I can reliably get 2X done in a day if I add a small amount of cannabis.
- EvRev 5y ago>Is there a solution to munchies? Lookup THCV, it is an analog that decreases your appetite along with a host of other benefits. Like you can consume any type of cannabis and then take a little THCV to counteract the munchies.
- mountainriver 5y agoYeah I don’t think we’ve tapped thcv yet, often called the sports car of cannabis
- neom 5y agoHadn't heard of it but seems interesting, thanks for posting. Here's a good in-depth article about it from a couple of days ago if anyone is interested: https://www.leafly.com/news/cannabis-101/everything-you-need-to-know-about-thcv-with-rare-cannabinoid-company https://www.leafly.com/news/cannabis-101/everything-you-need...
- bitxbitxbitcoin 5y agoSecond anecdata point for THCV for appetite suppressing, and the host of other benefits including memory improving.
- xerox13ster 5y agoAlso Linalool terpene dominant strains
- hattmall 5y agoHave you been diagnosed with ADHD? As to the productivity are you certain that you are more productive and not just feeling more productive? That's a pretty common thing with weed, it causes the brain to release dopamine which it normally does in response to you being productive.
- oblak 5y agoADHD wasn't a thing when I was a child. Does weed help with that? I've heard a lot of treating this condition with what is essentially legal amphetamines which sounds horrible to me. It's a shame, though not surprising in the least, that the good, cheap stuff is illegal in most of the world.
- balfirevic 5y ago> with what is essentially legal amphetamines which sounds horrible to me It's not.
- simlevesque 5y agoWhat is it not ? Legal amphetamine or horrible ?
- balfirevic 5y agoSorry, I realize now I wasn't clear. It's not horrible.
- schwartzworld 5y agoIt can help with ADHD. As far as the amphetamines, dosage, ROU and brain chemistry are everything. A 10mg Adderall is not the same thing as smoking 100mg of meth.
- deleted 5y ago[deleted]
- adreamingsoul 5y agoTalk to a doctor. Cannabis is complicated and we don’t yet have much research with humans due to Federal policy in the US.
- turndown 5y agoAs far as easy ways to microdose, obviously there are options such as chillums, but I personally love and use vaporizers. Very convenient, much less smell, and uses very little product. I'd recommend /r/vaporents if you are interested in learning more.
- hypertele-Xii 5y ago> Any solution to the tolerance problem? Cycle between different drugs. When you develop tolerance for one, switch to another. > Is there a way to microdose? I'd like to be able to have tiny, controlled amounts every time. Get a small vaporizer with degree-exact temperature control. Varying the temp even by 5 degrees between 175..230 degrees celsius produces very different types of high. Lower temperatures vaporize more CBD and less THC, leading to more body glow, while higher temps do the opposite and go to your head. Also, you don't have to inhale smoke and the dose is easier to control. > Is there a solution to munchies? ...Eat more? > Are my memory problems due to weed or is this just age? (When not using) I feel like I've lost lots of childhood memories and I have more difficulty than ever with names. Weed unlocked childhood memories I didn't remember having. But it also makes me draw blank, i.e. completely forget the train of thought or conversation. I think it's a strength/power, allowing you to discard useless memories.