You can't do intelligent drug design if you don't know what the target protein looks like. We've gotten great at solving protein structures with things like cry

You can't do intelligent drug design if you don't know what the target protein looks like. We've gotten great at solving protein structures with things like crystallography and cryo-EM microscopy. Unfortunately, many interesting drug targets reside in the membrane of a cell, which means you can't easily work with them in a lab because they aren't soluble in anything but a plasma membrane. For instance, this is an issue with the 5HT2A protein, a g coupled protein receptor that is implicated in many serotonin related pathways. Being able to predict what it would look like would be a huge deal because then you can go about intelligently designing drugs for it.