Compared to moving to another country? Yes it absolutely is. There are no legal impediments for moving to and living/working in another state for a US citizen.

Compared to moving to another country? Yes it absolutely is. There are no legal impediments for moving to and living/working in another state for a US citizen. This in contrast to even the EU, where despite freedom of movement, there are significant legal restrictions/requirments depending on state/jurisdiction for permanent alien residency. The only real impediment to moving between states as a US citizen is financial and social, but this is the case literally everywhere, even intrastate.