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Traditional vaccines != Genetic vector vaccines Traditional vaccines: Expose the immune system to an inactivated pathogen. The immune system stochastically lea
by bookofsand 5y ago
Traditional vaccines != Genetic vector vaccines
Traditional vaccines: Expose the immune system to an inactivated pathogen. The immune system stochastically learns to target a number of proteins specific to the pathogen.
Genetic vector vaccines: Expose a small number of cells to genetic material that instructs them to create a specific protein chosen by the vaccine developer. The immune system then learns to target this specific protein. The pathogen is under no obligation to continues to produce this specific protein, especially in face of the selection pressure produced by the genetic vector vaccines themselves. We are already talking of booster shots to tackle mutations, 6 month since we started large scale deployment. It's only going to get worse.
Open questions:
* Which protein(s) to chose.
* Why a single protein, rather than a mosaic.
* Is the protein(s) choice generic, or should it be personalized to a specific individual protein spectrum.
* What is the long term prognosis for world scale populations.
Cold fact: We have <1 years of world scale experience with genetic vector vaccines.
- lamontcg 5y agoWe have hundreds of years of experience with viral genetic vectors. There's a whole subfield of rheumatology dealing with autoimmune conditions triggered by viruses. The mRNA vaccines are just a single protein not the whole virus and it never gets assembled so its using considerably less cellular machinery than a real virus would. We've literally studied this shit for hundreds of years, and we're using less moving parts that would happen with a real infectious virus. Cold fact: this is not unknown territory at all.