3 ms·

Even weirder, according to that Wikipedia article, it doesn't appear to be necessary, or has very non-obvious implications when it's removed. Yet, it's present

Even weirder, according to that Wikipedia article, it doesn't appear to be necessary, or has very non-obvious implications when it's removed. Yet, it's present in almost all eucaryote cells...

Ericson2314 5y ago
The favorite nucleoprotein offspring of the ribosome elder gods shall not be disturbed in their nursery, lest a wrath beyond mere animo-younglings' understanding shall be unleashed.
opsbdb76 5y ago
Its well known what it does. The red pill activates it in 42% of all cells in your body and you wake up from your pod. Some people are known to surpass that threshold without taking a pill just reading HN comments. So be careful.
twic 5y ago
That is true for most things in the cell, though. There's an incredible amount of redundancy, optionality, and just plain unnecessary stuff. Vaults stick out because they're an apparently unnecessary thing that you can see down an electron microscope. There are many more equally unnecessary things that are just a lot smaller!
- f6v 5y ago
  > and just plain unnecessary stuff I'd like to point out that any protein that is produced takes up precious resources. Our evolutionary intuition suggests that unnecessary things should be dropped from the genome. Suppose a protein is unnecessary. Then there would be no evolutionary pressure to keep it from mutating and loosing its function(and mutations happen all the time!). The organisms would just gradually loose it to mutations and we wouldn't find a conserved protein throughout eucaryotes. So there must be something keeping it.
  - dash2 5y ago
    Could it be a genetic parasite?
    - BBC-vs-neolibs 5y ago
      Doesn't that go just a turtle deeper?
    - f6v 5y ago
      The genome is full of retrovirus remnants, so there’s a way for a parasite to piggyback on the host genome. Alu repeats in human genome are one such example. But there’s a hypothesis that these get “domesticated” by the genome and start serving a function.
    - quotemstr 5y ago
      One conserved over the whole tree of life? That's like imagining an editing bug that Emacs and Vim have both carefully and inexplicably preserved from the last universal common text editor.

Even weirder, according to that Wikipedia article, it doesn't appear to be necessary, or has very non-obvious implications when it's removed. Yet, it's present in almost all eucaryote cells...

Ericson2314 5y ago

The favorite nucleoprotein offspring of the ribosome elder gods shall not be disturbed in their nursery, lest a wrath beyond mere animo-younglings' understanding shall be unleashed.

opsbdb76 5y ago

Its well known what it does. The red pill activates it in 42% of all cells in your body and you wake up from your pod. Some people are known to surpass that threshold without taking a pill just reading HN comments. So be careful.

twic 5y ago

That is true for most things in the cell, though. There's an incredible amount of redundancy, optionality, and just plain unnecessary stuff. Vaults stick out because they're an apparently unnecessary thing that you can see down an electron microscope. There are many more equally unnecessary things that are just a lot smaller!

f6v 5y ago
> and just plain unnecessary stuff I'd like to point out that any protein that is produced takes up precious resources. Our evolutionary intuition suggests that unnecessary things should be dropped from the genome. Suppose a protein is unnecessary. Then there would be no evolutionary pressure to keep it from mutating and loosing its function(and mutations happen all the time!). The organisms would just gradually loose it to mutations and we wouldn't find a conserved protein throughout eucaryotes. So there must be something keeping it.
- dash2 5y ago
  Could it be a genetic parasite?
  - BBC-vs-neolibs 5y ago
    Doesn't that go just a turtle deeper?
  - f6v 5y ago
    The genome is full of retrovirus remnants, so there’s a way for a parasite to piggyback on the host genome. Alu repeats in human genome are one such example. But there’s a hypothesis that these get “domesticated” by the genome and start serving a function.
  - quotemstr 5y ago
    One conserved over the whole tree of life? That's like imagining an editing bug that Emacs and Vim have both carefully and inexplicably preserved from the last universal common text editor.