3 ms·
>For the winning research Ms. Bose looked at a chemotherapy drug, cisplatin, that is commonly taken by women with ovarian cancer. The problem is that the cancer
by scythe 15y ago
>For the winning research Ms. Bose looked at a chemotherapy drug, cisplatin, that is commonly taken by women with ovarian cancer. The problem is that the cancer cells tend to grow resistant to cisplatin over time, and Ms. Bose set out to find a way to counteract that.
Original study: https://sites.google.com/site/ampkandcisplatinresistance/ https://sites.google.com/site/ampkandcisplatinresistance/
Doesn't seem to have been published yet, but presumably it will be.
- bedris 15y agoVery nice work by a high school student! However, the hypothesis that AMPK can protect cells from cisplatin-induced cytotoxicity has been around for about four years: http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.00663.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2009.... http://www.jbc.org/content/283/7/3731.short http://www.jbc.org/content/283/7/3731.short