3 ms·
"You could say that TMZ is a prodrug for a prodrug for methyldiazonium, which is never going to be a drug that can just be administered by itself. ... temozolim
by mcguire 5y ago
"You could say that TMZ is a prodrug for a prodrug for methyldiazonium, which is never going to be a drug that can just be administered by itself. ... temozolimide is genotoxic and tetratogenic, so it has to be handled carefully, but honestly, anything that generates a small diazonium compound so readily is going to be similarly hazardous. ... Indeed, drop-hammer tests showed that these TMZ samples decompose suddenly with smoke on impact."
So, uh, what are the explosive decomposition products?