The short term overeating studies produce what we might call highly nonlinear results, which also undermines CICO (which is a linear equation). It's pretty obvi

The short term overeating studies produce what we might call highly nonlinear results, which also undermines CICO (which is a linear equation). It's pretty obvious the body has other ways to dump exceeds calories than turning them into fat stores. Those studies, and the obvious tendency of diets to fail in the long term, are strong support for some kind of lipostat system, to my mind. Others have mentioned gut biomes... My uneducated guess is plastics or some other chemical that was introduced into industrial use in the 20th century. The cross species effect (lab and zoo animals getting father on the same controlled diets) is also a really big clue that were dealing with a molecule. And, as with lead poisoning from gasoline, perhaps a hard to pinpoint one due to prevalence.