Let's not focus too much on the messenger and ad hominems, and focus on the message instead: "Is aging inevitable?", and does this Nature Communications paper[1

Let's not focus too much on the messenger and ad hominems, and focus on the message instead: "Is aging inevitable?", and does this Nature Communications paper[1] (note, that this isn't Nature proper, by the way) tell us something new about the answer? Well, the paper does not deal with genomic or molecular underpinnings of life, it only models the curves of species' lifespans and mortalities, and fits these to simple equations ... to find that the curves can indeed be fit, and the parameters indicate that the variability of lifespan in primates, as captured by the equation, is mostly explained by variability of early mortality. Mostly expected result, given no interventions significantly slowing/reversing aging have been approved by FDA as of now. Still, it's questionable as to why we don't see social stratification as a driver of human lifespan variability, as found in [2]. Overall, the paper is underwhelming compared to its title. Thus, the question remains open. The answer, at the very least, should explain the following: 1) How come some species[4], vertebrate species even, have more or less negligible senescence? [3][5] 2) How do specific alleles from lifespan GWAS influence human aging? [6] 3) What are precise molecular mechanisms underlying hallmarks of aging?[7] 4) Can these natural mechanisms be manipulated via therapeutic interventions to significantly change organism's lifespan? [8] If we accept the challenge and look at molecular biology of mammalian aging, we'll see whole new fields of science right there, waiting to be explored, some already bearing fruit, given we are witnessing more than a dozen human clinical trials on various senolytics[9] 1. https://www.nature.com/articles/s41467-021-23894-3 https://www.nature.com/articles/s41467-021-23894-3 2. https://jamanetwork.com/journals/jama/article-abstract/2513561 https://jamanetwork.com/journals/jama/article-abstract/25135... 3. https://en.wikipedia.org/wiki/Negligible_senescence https://en.wikipedia.org/wiki/Negligible_senescence 4. https://genomics.senescence.info/species/nonaging.php https://genomics.senescence.info/species/nonaging.php 5. https://pubmed.ncbi.nlm.nih.gov/31366472/ https://pubmed.ncbi.nlm.nih.gov/31366472/ 6. https://academic.oup.com/g3journal/article/9/9/2863/6026390 https://academic.oup.com/g3journal/article/9/9/2863/6026390 7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ 8. https://www.nature.com/articles/s41573-020-0067-7 https://www.nature.com/articles/s41573-020-0067-7 9. https://onlinelibrary.wiley.com/doi/full/10.1111/joim.13141 https://onlinelibrary.wiley.com/doi/full/10.1111/joim.13141