4 ms·

> Recent advances in amyloid imaging have made it possible to observe Aβ amyloid accumulation in the patient's brain. As a result, it has been found that there

> Recent advances in amyloid imaging have made it possible to observe Aβ amyloid accumulation in the patient's brain. As a result, it has been found that there are many normal patients with amyloid deposits, and also AD patients with very few amyloid deposits (Edison et al., 2007; Li et al., 2008). [0] How long is it going to take for the scientists who have built their career on the amyloid hypothesis to die out so new ideas can be investigated? [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797629/#s3title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797629/#s3titl...

anonuser123456 5y ago
One has to only look at the dumpster fire that is the USDA nutritional guidelines to know "never".
- AnimalMuppet 5y ago
  "Die out". Everybody dies eventually. It's just a long process waiting for science to progress by funerals.
  - quickthrowman 5y ago
    Indeed, plate tectonics (sort of, Wegener had the idea but no evidence/proof) and hand washing for doctors/surgeons both faced widespread opposition, just off the top of my head.
    - ficklepickle 5y ago
      mRNA is another example
  - heavyset_go 5y ago
    Not to worry, there are plenty of opportunists who will line up to carry the torch once the older ones die.
- tpush 5y ago
  What's wrong with the USDA nutritional guidelines?
  - deleted 5y ago
    [deleted]
  - BrianOnHN 5y ago
    > What's wrong Diabetes and obesity are still rampant, so I'd say something is certainly wrong.
    - sjfidsfkds 5y ago
      I’m not a fan of the guidelines myself (too carb-heavy, IMO). However I don’t think obesity and diabetes are rampant among people who eat 2000 calories and exercise 30 minutes per day.
      - deleted 5y ago
        [deleted]
      - anonuser123456 5y ago
        >However I don’t think obesity and diabetes are rampant among people who eat 2000 calories and exercise 30 minutes per day And this is where the issue gets complicated. Why do people eat more than 2000 calories / day and exercise less. Are they lazy and stupid, or is there something deeper. Personally, I think the most compelling argument appears to be that high insulin levels hijack the hypothalamus through hormonal disregulation. The hypothalamus of these insulin resistant people drives them to over eat and expend less energy because it thinks they are underfed. This model suggests severely restricting carbohydrate in order to drive down insulin levels.
        WA 5y ago
        You make it more complicated than it is: we have easy access to tons of calories, our lives don’t require us to move a lot and we are hardwired to find/eat calories and store them in the body for worse times. Low-carb certainly isn’t the solution. For some it is, but not for most.

anonuser123456 5y ago

One has to only look at the dumpster fire that is the USDA nutritional guidelines to know "never".

AnimalMuppet 5y ago
"Die out". Everybody dies eventually. It's just a long process waiting for science to progress by funerals.
- quickthrowman 5y ago
  Indeed, plate tectonics (sort of, Wegener had the idea but no evidence/proof) and hand washing for doctors/surgeons both faced widespread opposition, just off the top of my head.
  - ficklepickle 5y ago
    mRNA is another example
- heavyset_go 5y ago
  Not to worry, there are plenty of opportunists who will line up to carry the torch once the older ones die.
tpush 5y ago
What's wrong with the USDA nutritional guidelines?
- deleted 5y ago
  [deleted]
- BrianOnHN 5y ago
  > What's wrong Diabetes and obesity are still rampant, so I'd say something is certainly wrong.
  - sjfidsfkds 5y ago
    I’m not a fan of the guidelines myself (too carb-heavy, IMO). However I don’t think obesity and diabetes are rampant among people who eat 2000 calories and exercise 30 minutes per day.
    - deleted 5y ago
      [deleted]
    - anonuser123456 5y ago
      >However I don’t think obesity and diabetes are rampant among people who eat 2000 calories and exercise 30 minutes per day And this is where the issue gets complicated. Why do people eat more than 2000 calories / day and exercise less. Are they lazy and stupid, or is there something deeper. Personally, I think the most compelling argument appears to be that high insulin levels hijack the hypothalamus through hormonal disregulation. The hypothalamus of these insulin resistant people drives them to over eat and expend less energy because it thinks they are underfed. This model suggests severely restricting carbohydrate in order to drive down insulin levels.
      - WA 5y ago
        You make it more complicated than it is: we have easy access to tons of calories, our lives don’t require us to move a lot and we are hardwired to find/eat calories and store them in the body for worse times. Low-carb certainly isn’t the solution. For some it is, but not for most.