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The study that used a very high dose was an in vitro study from Spring 2020[1]. If anything, that study should be a proof that it is worth studying further. Th

The study that used a very high dose was an in vitro study from Spring 2020[1]. If anything, that study should be a proof that it is worth studying further. The dose makes the poison. The typical dose of Ivermectin for treating parasites (and Covid19) is 0.2mg/Kg. The LD50 is around >15mg/Kg in humans. Around the world it is one of the most administered medicines. AFAIK, not a single death has been attributed to it. Extremely safe. [1] https://www.sciencedirect.com/science/article/pii/S0166354220302011 https://www.sciencedirect.com/science/article/pii/S016635422...

perl4ever 5y ago
>The typical dose of Ivermectin for treating parasites (and Covid19) is 0.2mg/Kg. The LD50 is around >15mg/Kg in human I could easily be confused, since I've never taken a biology course after high school. However, here is what I get from your link. It mentions "addition of 5 μM ivermectin". I believe "5 μM" is a ratio, meaning 5 μmol per liter. Ivermectin is C48H74O14 so the weight of a mole is about 875g. By my arithmetic that comes out to about 4.4 mg per liter. So, if that can be loosely equated with the dosage "in vivo", assuming a liter is about a kg because everything is mostly water, it's more than 20 times the normal ratio, and nearly 1/3 of the LD50. I notice this comment: "no toxicity was observed with ivermectin at any of the concentrations tested" I may be missing something, but this seems like the comments about proving safety could be misleading or even disingenuous, if ivermectin's toxicity first or mainly applies to the nervous system and not the kind of cells they were experimenting with. What kind of cells were they using? It says "Vero/hSLAM". Vero = "kidney epithelial cells extracted from an African green monkey" and hSLAM means Vero cells "that have been stably transfected with a plasmid encoding the gene for the human [signaling lymphocytic activation molecule]" It's quite possible there's something very basic I don't understand, but after doing my best to interpret it, I would personally tend to qualify the results as "antiviral in dosages that are probably nontoxic to some parts of the kidneys of green monkeys". If was put on the spot, given such a dose for covid-19 purposes, I would not be very confident that it wouldn't be neurotoxic, even if I also believed it was less than the LD50. However, this all hinges on me understanding the dosage/ratio, and I may have screwed that up.

perl4ever 5y ago

>The typical dose of Ivermectin for treating parasites (and Covid19) is 0.2mg/Kg. The LD50 is around >15mg/Kg in human I could easily be confused, since I've never taken a biology course after high school. However, here is what I get from your link. It mentions "addition of 5 μM ivermectin". I believe "5 μM" is a ratio, meaning 5 μmol per liter. Ivermectin is C48H74O14 so the weight of a mole is about 875g. By my arithmetic that comes out to about 4.4 mg per liter. So, if that can be loosely equated with the dosage "in vivo", assuming a liter is about a kg because everything is mostly water, it's more than 20 times the normal ratio, and nearly 1/3 of the LD50. I notice this comment: "no toxicity was observed with ivermectin at any of the concentrations tested" I may be missing something, but this seems like the comments about proving safety could be misleading or even disingenuous, if ivermectin's toxicity first or mainly applies to the nervous system and not the kind of cells they were experimenting with. What kind of cells were they using? It says "Vero/hSLAM". Vero = "kidney epithelial cells extracted from an African green monkey" and hSLAM means Vero cells "that have been stably transfected with a plasmid encoding the gene for the human [signaling lymphocytic activation molecule]" It's quite possible there's something very basic I don't understand, but after doing my best to interpret it, I would personally tend to qualify the results as "antiviral in dosages that are probably nontoxic to some parts of the kidneys of green monkeys". If was put on the spot, given such a dose for covid-19 purposes, I would not be very confident that it wouldn't be neurotoxic, even if I also believed it was less than the LD50. However, this all hinges on me understanding the dosage/ratio, and I may have screwed that up.