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You wouldn't ask the question if you had developed both GUI apps on MS stack with VS and web apps: the MS dev experience is very good, while the web one is meh

You wouldn't ask the question if you had developed both GUI apps on MS stack with VS and web apps: the MS dev experience is very good, while the web one is meh at best. C# vs JS, XAML vs HTML+CSS (debatable), desktop application model vs web one, VS vs whatever else, there is a lot of strong arguments in favor of the MS stack in that case. Microsoft is trying to port some of this magic with Blazor, with is quite liked from what I read here and there.

interlocutor 5y ago
It is C# vs Typescript. Modern JavaScript is a very good language, and when enhanced with TypeScript's static types, it is every bit as good as C#. XAML and MVVM is all about two-way data binding. JS frameworks copied it at first. But now it is widely recognized that 2-way data binding is a bad idea. You can use for Web development too.