4 ms·

Physical phenotype of blood cells is altered in Covid-19

11 points by namu-313 5y ago

kaminar 5y ago
Warning: Link goes to browser, then tries to open another app. Possible scam/Trojan.
- kunagi7 5y ago
  Followed the link, the browser gets redirected to this PDF: https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf The document contains 32 pages about the subject.
- Tepix 5y ago
  It's ok. First a redirect to https://linkinghub.elsevier.com/retrieve/pii/S0006349521004549 https://linkinghub.elsevier.com/retrieve/pii/S00063495210045... then some javascript shenanigans then jumps to https://www.biophysj.org/retrieve/pii/S0006349521004549 https://www.biophysj.org/retrieve/pii/S0006349521004549 then to https://www.cell.com/biophysj/retrieve/pii/S0006349521004549 https://www.cell.com/biophysj/retrieve/pii/S0006349521004549 and finally https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf Going directly to the final PDF URL works as of right now but the previous URL is probably better in case they publish another revision. The paper is not yet final. Cell.com belongs to Elsevier.
tudorw 5y ago
I'm a layperson, on a read through this appears to have content that would a) enable a new testing method for covid that could offer higher throughput than PCR and b) describe functional changes brought about by covid that persist for 120 days beyond the infection that could be implicated in cases of long covid. "Since mature erythrocytes cannot synthesize new proteins to replace damaged ones and the average lifespan of erythrocytes is 120 days, the authors hypothesize that the circulation of irreversibly damaged erythrocytes with impaired function could contribute to the long-term effects of COVID-19 (25)"
- dfawcus 5y ago
  Also a layman, but I've a vague recall of reports of how a 4-5 day fast can trigger autophagy, followed by new cell generation once re-fed. So could that end up as a useful treatment? Or would it only help with the WBC, and not the RBC?

11 points by namu-313 5y ago

kaminar 5y ago

Warning: Link goes to browser, then tries to open another app. Possible scam/Trojan.

kunagi7 5y ago
Followed the link, the browser gets redirected to this PDF: https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf The document contains 32 pages about the subject.
Tepix 5y ago
It's ok. First a redirect to https://linkinghub.elsevier.com/retrieve/pii/S0006349521004549 https://linkinghub.elsevier.com/retrieve/pii/S00063495210045... then some javascript shenanigans then jumps to https://www.biophysj.org/retrieve/pii/S0006349521004549 https://www.biophysj.org/retrieve/pii/S0006349521004549 then to https://www.cell.com/biophysj/retrieve/pii/S0006349521004549 https://www.cell.com/biophysj/retrieve/pii/S0006349521004549 and finally https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf https://www.cell.com/biophysj/pdf/S0006-3495(21)00454-9.pdf Going directly to the final PDF URL works as of right now but the previous URL is probably better in case they publish another revision. The paper is not yet final. Cell.com belongs to Elsevier.

tudorw 5y ago

I'm a layperson, on a read through this appears to have content that would a) enable a new testing method for covid that could offer higher throughput than PCR and b) describe functional changes brought about by covid that persist for 120 days beyond the infection that could be implicated in cases of long covid. "Since mature erythrocytes cannot synthesize new proteins to replace damaged ones and the average lifespan of erythrocytes is 120 days, the authors hypothesize that the circulation of irreversibly damaged erythrocytes with impaired function could contribute to the long-term effects of COVID-19 (25)"

dfawcus 5y ago
Also a layman, but I've a vague recall of reports of how a 4-5 day fast can trigger autophagy, followed by new cell generation once re-fed. So could that end up as a useful treatment? Or would it only help with the WBC, and not the RBC?