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The Pfizer vaccine has cold chain requirements that mean it can't be used for half the world. It's also not clear if we're better off knocking down cases massiv

The Pfizer vaccine has cold chain requirements that mean it can't be used for half the world. It's also not clear if we're better off knocking down cases massively in some countries to prevent mutations or doing a slow (2+ year?) rollout across the world targeting the most at-risk, but at the risk of vaccine-resistant strains. That said, the US is looking like a pretty fertile breeding ground for a vaccine resistant strain.

ummonk 5y ago
Most of the world has no trouble with the cold chain requirements for their urban populations at least. Liquid nitrogen / oxygen is a common industrial good across the world. And vaccine resistant strains aren’t a big deal, as demonstrated in the new article - the vaccines are still 95% effective at preventing severe illness.
- ipaddr 5y ago
  They are still 95% effective after 6 months at preventing death. They are unknown effective against new variants. I've seen a variety of studies with different variants tested against Delta. At best I read 92% for Pfizer (but a previous test had them at 60%), other vaccines as low as 30%. The new variants like lambda have shown it responds to antibiotic poorly, it spreads quickly and is more deadly compared to delta. I'm not sure the vaccine strategy will continue to work.
  - pseudo0 5y ago
    Israel's Pfizer study has it at 64% effectiveness against Delta infection, but 94% against serious illness. That's still pretty decent. https://thehill.com/policy/healthcare/public-global-health/561627-pfizer-vaccine-less-effective-against-delta-variant https://thehill.com/policy/healthcare/public-global-health/5...
  - Doxin 5y ago
    Maybe I've misread, but why would you expect a virus to respond to antibiotics at all?
    - pbak 5y ago
      Some of the indirect effects of Covid are infection by opportunistic bacteria. They don't help you fight Covid per-se, they help you not die.
- deleted 5y ago
  [deleted]
- dehrmann 5y ago
  > ...as demonstrated in the new article These new strains aren't even close to vaccine resistant, yet. Vaccines haven't been around long enough for that.
- refurb 5y ago
  Liquid oxygen? You can use it for cooling things. Not safely at least.
ipaddr 5y ago
What we are seeing is new variants coming from large populations around the globe. Delta is here. Lambda has just arrived. The Vietam variant which is delta+the British no one is talking about.. it will soon have a name. Better to lockdown, vaccinate those populations before giving a third or fourth or weekly dose. Saving Pfizer doses means other brands can go to hotter climates.
- pbak 5y ago
  It took us 6 months to vaccinate 400-500 mil. people in industrial nations with the best logistics systems on the planet. We won't even be able to vaccinate the rest with basic doses for 7 years at a minimum at this rate. Alternatively, we produce cheap prophylactic drugs in industrial quantities and flood the battlefield.
  - votepaunchy 5y ago
    Bloomberg reports 3.35 billion doses administered, 10% in the US alone. We also have unknown tens or hundreds of millions of unused (and expiring) doses we have been unwilling to share with the world (as we continue to manufacture millions more per day). Most of the 6 months has been scaling up (and fixing) production, same reason iPhones are in short supply on release day. https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/ https://www.bloomberg.com/graphics/covid-vaccine-tracker-glo...
    - pbak 5y ago
      I was wrong on the numbers. I have gone through the article. Still won't be done by early 2023, even at this rate. Logistics are hell, outside of urban centers.
  - ummonk 5y ago
    That was limited by manufacturing not logistics. If we continue scaling up manufacturing (and not diverting it to unnecessary uses like booster doses), the world can get vaccinated in a reasonable time frame.
senectus1 5y ago
The Us is already producing a new strain.. B1526 is iota

ummonk 5y ago

Most of the world has no trouble with the cold chain requirements for their urban populations at least. Liquid nitrogen / oxygen is a common industrial good across the world. And vaccine resistant strains aren’t a big deal, as demonstrated in the new article - the vaccines are still 95% effective at preventing severe illness.

ipaddr 5y ago
They are still 95% effective after 6 months at preventing death. They are unknown effective against new variants. I've seen a variety of studies with different variants tested against Delta. At best I read 92% for Pfizer (but a previous test had them at 60%), other vaccines as low as 30%. The new variants like lambda have shown it responds to antibiotic poorly, it spreads quickly and is more deadly compared to delta. I'm not sure the vaccine strategy will continue to work.
- pseudo0 5y ago
  Israel's Pfizer study has it at 64% effectiveness against Delta infection, but 94% against serious illness. That's still pretty decent. https://thehill.com/policy/healthcare/public-global-health/561627-pfizer-vaccine-less-effective-against-delta-variant https://thehill.com/policy/healthcare/public-global-health/5...
- Doxin 5y ago
  Maybe I've misread, but why would you expect a virus to respond to antibiotics at all?
  - pbak 5y ago
    Some of the indirect effects of Covid are infection by opportunistic bacteria. They don't help you fight Covid per-se, they help you not die.
deleted 5y ago
[deleted]
dehrmann 5y ago
> ...as demonstrated in the new article These new strains aren't even close to vaccine resistant, yet. Vaccines haven't been around long enough for that.
refurb 5y ago
Liquid oxygen? You can use it for cooling things. Not safely at least.

ipaddr 5y ago

What we are seeing is new variants coming from large populations around the globe. Delta is here. Lambda has just arrived. The Vietam variant which is delta+the British no one is talking about.. it will soon have a name. Better to lockdown, vaccinate those populations before giving a third or fourth or weekly dose. Saving Pfizer doses means other brands can go to hotter climates.

pbak 5y ago
It took us 6 months to vaccinate 400-500 mil. people in industrial nations with the best logistics systems on the planet. We won't even be able to vaccinate the rest with basic doses for 7 years at a minimum at this rate. Alternatively, we produce cheap prophylactic drugs in industrial quantities and flood the battlefield.
- votepaunchy 5y ago
  Bloomberg reports 3.35 billion doses administered, 10% in the US alone. We also have unknown tens or hundreds of millions of unused (and expiring) doses we have been unwilling to share with the world (as we continue to manufacture millions more per day). Most of the 6 months has been scaling up (and fixing) production, same reason iPhones are in short supply on release day. https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/ https://www.bloomberg.com/graphics/covid-vaccine-tracker-glo...
  - pbak 5y ago
    I was wrong on the numbers. I have gone through the article. Still won't be done by early 2023, even at this rate. Logistics are hell, outside of urban centers.
- ummonk 5y ago
  That was limited by manufacturing not logistics. If we continue scaling up manufacturing (and not diverting it to unnecessary uses like booster doses), the world can get vaccinated in a reasonable time frame.

senectus1 5y ago

The Us is already producing a new strain.. B1526 is iota