3 ms·
I remember a Phase 1 Trial for a drug (TGN1412), all six volunteers suffered serious reactions within an hour of being dosed. Four suffered multiple organ failu
by Gibbon1 5y ago
I remember a Phase 1 Trial for a drug (TGN1412), all six volunteers suffered serious reactions within an hour of being dosed. Four suffered multiple organ failure.
https://en.wikipedia.org/wiki/Theralizumab https://en.wikipedia.org/wiki/Theralizumab
- sterlind 5y agothe trial design for that was extremely negligent. Phase 1 dosages - which should be low for first-in-man - far exceeded what was tested in animals by mg/kg, resulting in the drug completely saturating its target receptor. Derek Lowe covered the story years back when it happened, my knowledge comes from him and wikipedia. edit: not to mentioned they dosed six people at once! what the hell?