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Any reason for ibuprofen instead of paracetamol? Ibuprofen can damage your gastrointestinal tract.

by vultour 5y ago

TheCoelacanth 5y ago
Paracetamol can damage your liver. Neither are great options to take too much of.
- filoeleven 5y ago
  More research is being done nowadays on various terpenes for pain relief. Unfortunately, because it’s strongly associated the cannabis industry, it’s hard to get past all the noise to the good information like research papers. Most of the terpenes in cannabis strains are also found in other plants to varying degrees. Pure extracts are available and legal without question. I can’t say much about their efficacy though, because I haven’t done a deep dive. Id love to hear from anyone who has done the research or has personal experience, especially without THC or CBD along for the ride.
  - buu700 5y ago
    I had a similar thought, but in the other direction. I would be very curious to see how controlled doses of cannabinoids / cannabis oils compare to common opioid prescriptions for severe chronic and acute pain. As far as terpenes specifically, I've been hearing some recent positive buzz about linalool.
- Ieghaehia9 5y ago
  As I understand it, paracetamol was discovered as the active metabolite of a much more damaging drug (acetanilide); and that most of paracetamol's effects is due to a metabolite of paracetamol in turn, namely AM404. Why the pharmaceutical companies haven't done to paracetamol what they did to acetanilide, I don't understand. Providing AM404 directly would avoid the production of NAPQI in the body.
nonameiguess 5y ago
For me, I choose ibuprofen more often than paracetamol because 1) paracetamol carries a fairly serious overdose risk and is one of the common drugs people accidentally kill themselves with, and 2) paracetamol is not a true anti-inflammatory and doesn't help nearly as much with arthritis. Ibuprofen doesn't just relieve pain but actively reduces inflammation.

Any reason for ibuprofen instead of paracetamol? Ibuprofen can damage your gastrointestinal tract.

TheCoelacanth 5y ago

Paracetamol can damage your liver. Neither are great options to take too much of.

filoeleven 5y ago
More research is being done nowadays on various terpenes for pain relief. Unfortunately, because it’s strongly associated the cannabis industry, it’s hard to get past all the noise to the good information like research papers. Most of the terpenes in cannabis strains are also found in other plants to varying degrees. Pure extracts are available and legal without question. I can’t say much about their efficacy though, because I haven’t done a deep dive. Id love to hear from anyone who has done the research or has personal experience, especially without THC or CBD along for the ride.
- buu700 5y ago
  I had a similar thought, but in the other direction. I would be very curious to see how controlled doses of cannabinoids / cannabis oils compare to common opioid prescriptions for severe chronic and acute pain. As far as terpenes specifically, I've been hearing some recent positive buzz about linalool.
Ieghaehia9 5y ago
As I understand it, paracetamol was discovered as the active metabolite of a much more damaging drug (acetanilide); and that most of paracetamol's effects is due to a metabolite of paracetamol in turn, namely AM404. Why the pharmaceutical companies haven't done to paracetamol what they did to acetanilide, I don't understand. Providing AM404 directly would avoid the production of NAPQI in the body.

nonameiguess 5y ago

For me, I choose ibuprofen more often than paracetamol because 1) paracetamol carries a fairly serious overdose risk and is one of the common drugs people accidentally kill themselves with, and 2) paracetamol is not a true anti-inflammatory and doesn't help nearly as much with arthritis. Ibuprofen doesn't just relieve pain but actively reduces inflammation.