If you're getting in touch with people directly, friday afternoon is probably less effective. (Although you could also catch someone bored and waiting to go hom

If you're getting in touch with people directly, friday afternoon is probably less effective. (Although you could also catch someone bored and waiting to go home that reads it immediately; less so these days). Monday morning may also be bad because there may be pressing stuff to deal with after the weekend. For submitting an application to a job posting, they generally just get collected as they come in, then screened all at once, so when you send it doesn't matter.