Life almost by definition is not the lowest energy state matter can exist at. Thus living proteins may need some extra energy care and maintenance to maintain t

Life almost by definition is not the lowest energy state matter can exist at. Thus living proteins may need some extra energy care and maintenance to maintain their functional form. Without this active input, they may relax into a form that from one perspective is "mis-folded" but from another perspective is just the natural lower energy state the collection of atoms is expected to be found in if nothing is maintaining it. So maybe instead of "stop misfolding" it is provide adequate maintenance infrastructure and budget. But the maintenance workers (mitochondria) have a much more active life than the sedentary (brain) cells they inhabit and have suffered through many cell divisions each with their accumulation of errors till at some point just like all us worker drones, have no fscks left to give.