3 ms·
The 'amyloid hypothesis' as the protein being the cause of Alzheimer's has been the most popular for a few decades, so it's not surprising you've read so much a
by kinjba11 5y ago
The 'amyloid hypothesis' as the protein being the cause of Alzheimer's has been the most popular for a few decades, so it's not surprising you've read so much about it. But there hasn't been much success in drugs targeting the protein. New evidence suggests that there could be an underlying cause.
I'm a fan of the theory that bacteria/viruses are a cause and that the proteins we see are an overkill immune response to that (wouldn't be the first time - influenza/covid kill some not directly but via the immune system over-doing it).
See https://www.nature.com/articles/d41586-018-05719-4 https://www.nature.com/articles/d41586-018-05719-4 for more details.
- dnautics 5y agowhen i was a grad student in an amyloid lab (2009-ish) we were already doubting the amyloid hypothesis. Not so much the PIs. It's kind of wierd to see these ideas finally catching hold today. But when the grant money is coming in, you're gonna push your hypothesis hard. That said, IMO we really don't know. I worked on figuring out how to make these experiments more reproducible. My paper is cited a TON, but whenever I peek into the field, people are still are using shitty techniques, even the papers citing me.... Feels like "you didn't read the paper, did you?".
- EMM_386 5y ago> I'm a fan of the theory that bacteria/viruses are a cause and that the proteins we see are an overkill immune response to that That would be ... bad ... given that we just had a lot of the world exposed to Covid, and then we just vaccinated everyone to ramp up the immune system.