I was just watching “Reversing Dementia with diet, 2021 update - dr Paul Mason”[1] he makes the quite convincing case that it’s a metabolic disorder not a gene

I was just watching “Reversing Dementia with diet, 2021 update - dr Paul Mason”[1] he makes the quite convincing case that it’s a metabolic disorder not a genetic one, that incidence is increasing due to western diet and lifestyle (as with so many things), and that particularly fructose, and oxidised unsaturated fats and seed oils are implicated in the formation of amyloid plaque, in insulin resistance and therefore starvation of brain tissue, in damage to the blood brain barrier. And that reducing these things can reduce the chance of developing these diseases, that ketones from a ketogenic diet can bypass insulin resistance and provide brain fuel which improves symptoms in people who have these diseases, and that apoE is about cleaning up plaques and variant 4 most associated with Alzheimers is the most easily damaged one and therefore less effective at cleanup in metabolically unhealthy people - but less necessary in metabolically healthy people who aren’t creating as many tangles to clear up. It is not the first time I’ve seen claims along these lines - dementia as type 3 diabetes, brain function in elderly people improved with diet changes, etc. If insulin resistance of the blood brain barrier in middle age causes brain cells to starve to death, and that’s what causes the brain dysfunction and symptoms it doesn’t bode well for ever finding a “cure” anymore than there could be a drug cure for a missing limb. [1] https://www.youtube.com/watch?v=muAvJ1y64PA https://www.youtube.com/watch?v=muAvJ1y64PA