3 ms·

I found one relevant article (Response to the article) on PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833091/ https://www.ncbi.nlm.nih.gov/pmc/articl

I found one relevant article (Response to the article) on PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833091/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833091/ "Although this is not the case of the authorized COVID-19 mRNA vaccines, future formulations containing adjuvant like TLR agonists [13] may exacerbate pre-existing autoimmune or autoinflammatory disorders and should therefore be discouraged in this cohort of patients." I guess this mostly relates to the "packaging" of the mRNA vaccines relating to the entry in the cells.

giantg2 5y ago
Yeah, I saw that one. But the cohort of patients it's talking about already have autoimmune issues and the focus is on the adjunctives. I think there was another one talking about 50% of severe covid patients developing autoimmune antibodies, but with no idea if they will progress to a condition. I was hoping to see some longterm studies from prior mRNA research. But it's my understanding that the longer research wasn't about inducing immune response but for trying to modify DNA to correct genetic conditions (which failed, but now crispr...).
- kasperset 5y ago
  I found few case studies for blood clotting which could be due to autoimmune origin. However, no formal studies yet that I could find. Maayan, H., Kirgner, I., Gutwein, O., Herzog-Tzarfati, K., Rahimi-Levene, N., Koren-Michowitz, M., & Blickstein, D. (n.d.). Acquired Thrombotic Thrombocytopenic Purpura: A rare disease associated Acquired with BNT162b2 vaccine. Journal of Thrombosis and Haemostasis, n/a(n/a). https://doi.org/10.1111/jth.15420 https://doi.org/10.1111/jth.15420 Yocum, A., & Simon, E. L. (2021). Thrombotic Thrombocytopenic Purpura after Ad26.COV2-S Vaccination. The American Journal of Emergency Medicine. https://doi.org/10.1016/j.ajem.2021.05.001 https://doi.org/10.1016/j.ajem.2021.05.001

giantg2 5y ago

Yeah, I saw that one. But the cohort of patients it's talking about already have autoimmune issues and the focus is on the adjunctives. I think there was another one talking about 50% of severe covid patients developing autoimmune antibodies, but with no idea if they will progress to a condition. I was hoping to see some longterm studies from prior mRNA research. But it's my understanding that the longer research wasn't about inducing immune response but for trying to modify DNA to correct genetic conditions (which failed, but now crispr...).

kasperset 5y ago
I found few case studies for blood clotting which could be due to autoimmune origin. However, no formal studies yet that I could find. Maayan, H., Kirgner, I., Gutwein, O., Herzog-Tzarfati, K., Rahimi-Levene, N., Koren-Michowitz, M., & Blickstein, D. (n.d.). Acquired Thrombotic Thrombocytopenic Purpura: A rare disease associated Acquired with BNT162b2 vaccine. Journal of Thrombosis and Haemostasis, n/a(n/a). https://doi.org/10.1111/jth.15420 https://doi.org/10.1111/jth.15420 Yocum, A., & Simon, E. L. (2021). Thrombotic Thrombocytopenic Purpura after Ad26.COV2-S Vaccination. The American Journal of Emergency Medicine. https://doi.org/10.1016/j.ajem.2021.05.001 https://doi.org/10.1016/j.ajem.2021.05.001