Took me quite some time to find the paper that seemed to describe the ML algo[1]. Pretty disappointingly domain-specific and barebones ("logistic regression").

Took me quite some time to find the paper that seemed to describe the ML algo[1]. Pretty disappointingly domain-specific and barebones ("logistic regression"). And indeed, model form was so unimportant that it was relegated to the supplement. [2] Yet again evidence that access to data and domain knowledge trump fancy ML algos 10/10 times. [1] https://www.sciencedirect.com/science/article/pii/S0923753420360580 https://www.sciencedirect.com/science/article/pii/S092375342... [2] > Custom software was built to classify samples using source models that recognized methylation patterns per region as similar to those derived from a particular cancer type, fol- lowed by a pair of ensemble logistic regressions: one to determine cancer/non-cancer status and the other to resolve the TOO to one of the listed sites (supplementary information)