4 ms·

1) It's Richard Ebright who has been quoted in numerous articles. He isn't some "rando on twitter." You didn't read his sub-tweets. 2) You only read the title

1) It's Richard Ebright who has been quoted in numerous articles. He isn't some "rando on twitter." You didn't read his sub-tweets. 2) You only read the title of the article I linked that was in sub-tweets. See the following tweet: https://mobile.twitter.com/R_H_Ebright/status/1405239192628645895 https://mobile.twitter.com/R_H_Ebright/status/14052391926286... > The construction of novel chimeric SARS-related coronaviruses able to infect human cells and lab animals at WIV (1) was published with acknowledgment to NIH grant AI110964 (https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698 https://journals.plos.org/plospathogens/article?id=10.1371/j...) and (2) was reported to NIH under NIH grant AI110964 (https://reporter.nih.gov/search/0dVX_GElSEGDOsNMZq7qaQ/project-details/9819304#publications https://reporter.nih.gov/search/0dVX_GElSEGDOsNMZq7qaQ/proje...) So, yes, gain of function research was happening at WIV.

lamontcg 5y ago
There's not gain of function. The WIV1 virus already binds to hACE2, putting another spike on it and finding that spike also binds to hACE2 in vitro doesn't enhance its function at all. It does tell you how much that spike binds to hACE2. You can debate if that's a good idea or not, but SARS-CoV-2 is way too distant from WIV1/SARS-CoV-1 to arise from any lab experiment with chimeric viruses. And its also too far away from RaTG13, which still needs decades of evolution to turn into SARS-CoV-2.
- ketamine__ 5y ago
  https://mobile.twitter.com/R_H_Ebright/status/1405239128053227525 https://mobile.twitter.com/R_H_Ebright/status/14052391280532... > The work met--unequivocally--the definition of gain-of-function research of concern under the 2014 Pause. > The work met--unequivocally--the definition of potential pandemic pathogen enhancement under the 2017 HHS Potential Pandemic Pathogen Control and Oversight (P3CO) Framework.

lamontcg 5y ago

There's not gain of function. The WIV1 virus already binds to hACE2, putting another spike on it and finding that spike also binds to hACE2 in vitro doesn't enhance its function at all. It does tell you how much that spike binds to hACE2. You can debate if that's a good idea or not, but SARS-CoV-2 is way too distant from WIV1/SARS-CoV-1 to arise from any lab experiment with chimeric viruses. And its also too far away from RaTG13, which still needs decades of evolution to turn into SARS-CoV-2.

ketamine__ 5y ago
https://mobile.twitter.com/R_H_Ebright/status/1405239128053227525 https://mobile.twitter.com/R_H_Ebright/status/14052391280532... > The work met--unequivocally--the definition of gain-of-function research of concern under the 2014 Pause. > The work met--unequivocally--the definition of potential pandemic pathogen enhancement under the 2017 HHS Potential Pandemic Pathogen Control and Oversight (P3CO) Framework.