When I've done this, on first boot Windows detects the changed hardware and there's a little mini-installation screen that says "Reconfiguring Hardware" or some

When I've done this, on first boot Windows detects the changed hardware and there's a little mini-installation screen that says "Reconfiguring Hardware" or something. Things seem to work afterwards. Changing the Motherboard may cause activation issues on OEM licenses. Changing from Nvidia GPUs to other manufacturers may require e.g. DDU to remove their drivers completely.