This blows my mind. Throwing your prime (or prime-st remaining years) at an office. Can you put your foot down and take unpaid leave whether they like it or not

This blows my mind. Throwing your prime (or prime-st remaining years) at an office. Can you put your foot down and take unpaid leave whether they like it or not? Come up with an excuse if you have to. They will always try to push you to follow their line but will you regret that later in life?