Yeah I see threads of this sort of argument coming from many different angles. I just ran across this paper[1] via a youtube review[2] which was mainly focused

Yeah I see threads of this sort of argument coming from many different angles. I just ran across this paper[1] via a youtube review[2] which was mainly focused on diet/nutrition and metabolism, but again is looking at mitochondria and possible neurological connections. "The continuum of disrupted metabolic tempo, mitochondrial substrate congestion, and metabolic gridlock toward the development of non-communicable diseases": The bioenergetic dysregulation could also prime for the emerging of [neurodegenerative disorders] (O’Neill and O’Driscoll 2015; Pugazhenthi, Qin, and Reddy 2017). Hyperglycemia, obesity and hyperglycemia could induce the extracellular amyloid b (Ab) plaques, hyperphosphorylated tau protein, neuronal loss, and cognitive dysfunction, while the Ab plaques might reciprocally induce [insulin resistance]. Together with the inflammation and oxidative stress, the hyperglycemic-generated advanced glycation end products (AGE) are also the critical cause of neurodegeneration (de Nazareth 2017; Pugazhenthi, Qin, and Reddy 2017). There is a decrease in the brian-derived neuro-trophic factors (BDNF) in both MetS and NDDs, such as Alzheimer’s disease (AD), Huntington’s disease, Parkinson’s disease, and depression (Motamedi, Karimi, and Jafari 2017). The concurrent mitochondrial dysfunction in obesity, T2D, and [insulin resistance] ultimately causes cognitive dysfunction (Pugazhenthi, Qin, and Reddy 2017). All these interrelated pathophysiologies suggest the common pathophysiologies of NCDs and NDDs. Prolonged bioenergetic dysregulation thus potentially contribute to cognitive dysfunction. The tldr is you should go through periods of fed and fasted state metabolically (what they refer to as "pushing" and "pulling" energy into/from your body) - most Americans are constantly in the fed/pushing state which leads to metabolic dysregulation. Under this paradigm switching to a ketogenic diet would help restore metabolic function and lead to more time spent in the pulling state (due to lower insulin). [1] https://www.researchgate.net/publication/352475880_The_continuum_of_disrupted_metabolic_tempo_mitochondrial_substrate_congestion_and_metabolic_gridlock_toward_the_development_of_non-communicable_diseases https://www.researchgate.net/publication/352475880_The_conti... (full text) [2] https://www.youtube.com/watch?v=WthvGKTKOH4 https://www.youtube.com/watch?v=WthvGKTKOH4