4 ms·

Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware

Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware of when accepting an mRNA shot?

captainredbeard 5y ago
It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.
- ganzuul 5y ago
  I don't understand what you are saying. What is the significance of either of those?
- lima 5y ago
  And cytotoxicity - with the second shot, the body will have cytotoxic T cells which could target some of the transfected cells. But, why not to be worried: - It's a normal process and most cells will be replaced. - The effects would be tiny, especially compared to an infection with the real thing. If this was causing widespread issues, we would know by now. - All studies done so far indicate that only a very small amount will enter systemic circulation. It's a classic risk tradeoff, and the risks of taking the vaccine are much smaller than the risk of getting the real infection (billions of viruses replicating vs. one-time dose, real spike protein vs. stabilized spike protein).
- Majromax 5y ago
  > It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes. The mRNA vaccines are designed to express the spike protein in a membrane-bound form; very little is found floating free. See https://www.deplatformdisease.com/blog/spike-protein-circulating-in-the-vaccinated-what-does-it-mean https://www.deplatformdisease.com/blog/spike-protein-circula.... Additionally, the mRNA vaccines express a modified spike protein that is stabilized in its "prefusion" state (as seen on the virus itself before it binds with a cell), and the resulting complex seems to have somewhat fewer effects even when it does interact with a cell.
megous 5y ago
This + side-effects not going away as advertised. Finding some longer term side effect studies is not that easy in general search engine, due to slew of regurgitated basic information about side effects. Would be nice to have some data, instead of a ton of articles that say the same old "most symptoms go away within a few days". How does one decide whether to vaccinate or not based on such information? What is most? What is few days? Some side effects are extremely common, like shoulder pain. Acceptable if it goes away in a week, let's say. But if there's a risk I'll have it for 3 months or forever, I'd like to know how common is that to make a calculated risk assessment. < 1% probably acceptable. >2-3% probably not. And this will only be more apparent with time and more studies. The study I managed to find tracked people only for 8 days, had a nice graph of symptoms fading away with time. Mind calming exponential decay. :) Good, but 5% still had some symptoms at day 8. How many do have them at day 60? I don't understand why such information has to be so hard to find for normal people, who don't spend days searching around on google scholar.

Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware of when accepting an mRNA shot?

captainredbeard 5y ago

It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.

ganzuul 5y ago
I don't understand what you are saying. What is the significance of either of those?
lima 5y ago
And cytotoxicity - with the second shot, the body will have cytotoxic T cells which could target some of the transfected cells. But, why not to be worried: - It's a normal process and most cells will be replaced. - The effects would be tiny, especially compared to an infection with the real thing. If this was causing widespread issues, we would know by now. - All studies done so far indicate that only a very small amount will enter systemic circulation. It's a classic risk tradeoff, and the risks of taking the vaccine are much smaller than the risk of getting the real infection (billions of viruses replicating vs. one-time dose, real spike protein vs. stabilized spike protein).
Majromax 5y ago
> It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes. The mRNA vaccines are designed to express the spike protein in a membrane-bound form; very little is found floating free. See https://www.deplatformdisease.com/blog/spike-protein-circulating-in-the-vaccinated-what-does-it-mean https://www.deplatformdisease.com/blog/spike-protein-circula.... Additionally, the mRNA vaccines express a modified spike protein that is stabilized in its "prefusion" state (as seen on the virus itself before it binds with a cell), and the resulting complex seems to have somewhat fewer effects even when it does interact with a cell.

megous 5y ago

This + side-effects not going away as advertised. Finding some longer term side effect studies is not that easy in general search engine, due to slew of regurgitated basic information about side effects. Would be nice to have some data, instead of a ton of articles that say the same old "most symptoms go away within a few days". How does one decide whether to vaccinate or not based on such information? What is most? What is few days? Some side effects are extremely common, like shoulder pain. Acceptable if it goes away in a week, let's say. But if there's a risk I'll have it for 3 months or forever, I'd like to know how common is that to make a calculated risk assessment. < 1% probably acceptable. >2-3% probably not. And this will only be more apparent with time and more studies. The study I managed to find tracked people only for 8 days, had a nice graph of symptoms fading away with time. Mind calming exponential decay. :) Good, but 5% still had some symptoms at day 8. How many do have them at day 60? I don't understand why such information has to be so hard to find for normal people, who don't spend days searching around on google scholar.