4 ms·

" But since there hadn't been a randomized trial " This is not true. A quick search shows 71 trials covering ivermectin, of which 6 of which are complete, inte

by ajb 5y ago

" But since there hadn't been a randomized trial " This is not true. A quick search shows 71 trials covering ivermectin, of which 6 of which are complete, interventional[1], and have results https://clinicaltrials.gov/ct2/results?term=ivermectin&cond=COVID-19&Search=Apply&recrs=e&age_v=&gndr=&type=&rslt= https://clinicaltrials.gov/ct2/results?term=ivermectin&cond=... [1] This should mean an RCT, but I haven't time to read through each and check they are

PragmaticPulp 5y ago
Yes, it has been explored, trialed, and experimented with quite significantly. The results show that there might be something there, but it’s not a miracle cure. The conspiracy angles are coming from those who have been misled into thinking it has been more successful than it really has been, which leads to confusion about why it’s not being used everywhere.
- spfzero 5y ago
  With 0.38 risk ratio, it may well be that it should be used everywhere (except for patients already advanced enough to need mechanical ventilation, as mentioned). I don't have a reference for this but I recently read it was basically used on every tested-positive case with symptoms in Mexico City, with significantly improved results.
  - The_rationalist 5y ago
    How do you calculate the risk ratio?
    - bamboozled 5y ago
      It's been in use for about 40 years and prescribed maybe billions of times, conclusions would've been drawn from a large data set like that.
- injb 5y ago
  > The conspiracy angles are coming from those who have been misled into thinking it has been more successful than it really has been, which leads to confusion about why it’s not being used everywhere. No, the "conspiracy angles" are coming from people who have seen youtube videos and HN posts disappearing just for discussing it.
  - jean_valje4n 5y ago
    Well a lot of people with biochem background also have a lot of skepticism about it too. Ivermectin works by interrupting nerve function of helminths(parasites). covid is a virus, not a multicellular organism with nerves. I'm not saying ivermectin is useless, but why it would work for covid doesn't make sense (yet at least). Maybe it has some other mechanism to slow down covid that isn't fully understood.
    - galangalalgol 5y ago
      there were some studies that seemed to show that it shrank melanomas. my guess is it is triggering the immune system response. but i just write software, so dont go chugging horse dewormer instead of seeing a doctor because this smart guy on hn said it would get rid of your melanoma.
      - noduerme 5y ago
        This. A lot of things generate a broad immune response that would probably improve mild to moderate cases of just about anything. My gf secretly switched my usual horse dewormer for Sanka. On the third day I ate the postman, but I haven't had covid since.
    - argvargc 5y ago
      You don't seem to know what you're talking about. The mechanism by which Ivermectin works does make sense, and has been well-established. Look up any of the many binding studies on pubmed for example. Regardless of this, the results of the great many RCT's speak for themselves. https://ivmmeta.com https://ivmmeta.com

by ajb 5y ago

PragmaticPulp 5y ago

Yes, it has been explored, trialed, and experimented with quite significantly. The results show that there might be something there, but it’s not a miracle cure. The conspiracy angles are coming from those who have been misled into thinking it has been more successful than it really has been, which leads to confusion about why it’s not being used everywhere.

spfzero 5y ago
With 0.38 risk ratio, it may well be that it should be used everywhere (except for patients already advanced enough to need mechanical ventilation, as mentioned). I don't have a reference for this but I recently read it was basically used on every tested-positive case with symptoms in Mexico City, with significantly improved results.
- The_rationalist 5y ago
  How do you calculate the risk ratio?
  - bamboozled 5y ago
    It's been in use for about 40 years and prescribed maybe billions of times, conclusions would've been drawn from a large data set like that.
injb 5y ago
> The conspiracy angles are coming from those who have been misled into thinking it has been more successful than it really has been, which leads to confusion about why it’s not being used everywhere. No, the "conspiracy angles" are coming from people who have seen youtube videos and HN posts disappearing just for discussing it.
- jean_valje4n 5y ago
  Well a lot of people with biochem background also have a lot of skepticism about it too. Ivermectin works by interrupting nerve function of helminths(parasites). covid is a virus, not a multicellular organism with nerves. I'm not saying ivermectin is useless, but why it would work for covid doesn't make sense (yet at least). Maybe it has some other mechanism to slow down covid that isn't fully understood.
  - galangalalgol 5y ago
    there were some studies that seemed to show that it shrank melanomas. my guess is it is triggering the immune system response. but i just write software, so dont go chugging horse dewormer instead of seeing a doctor because this smart guy on hn said it would get rid of your melanoma.
    - noduerme 5y ago
      This. A lot of things generate a broad immune response that would probably improve mild to moderate cases of just about anything. My gf secretly switched my usual horse dewormer for Sanka. On the third day I ate the postman, but I haven't had covid since.
  - argvargc 5y ago
    You don't seem to know what you're talking about. The mechanism by which Ivermectin works does make sense, and has been well-established. Look up any of the many binding studies on pubmed for example. Regardless of this, the results of the great many RCT's speak for themselves. https://ivmmeta.com https://ivmmeta.com