3 ms·

I Googled Ivermectin meta-analysis. But instead of finding the article we're discussing now, I found a different meta-analysis. https://www.medrxiv.org/conte

I Googled Ivermectin meta-analysis. But instead of finding the article we're discussing now, I found a different meta-analysis. https://www.medrxiv.org/content/10.1101/2021.05.21.21257595v1 https://www.medrxiv.org/content/10.1101/2021.05.21.21257595v... It concluded Ivermectin "did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have effect on AEs or SAEs. IVM is not a viable option to treat COVID-19 patients." But wait... Before you upvote or downvote me, I want to say this proves something entirely different than what we may think. It proves that there's lots of studies -- some say one thing, some say another. I can produce a study which seems to convincingly prove one side of an issue -- and somebody else can produce a different study which seems to show the opposite.

zanethomas 5y ago
compare to duckduckgo results https://duckduckgo.com/?t=ffab&q=+Ivermectin+meta-analysis&atb=v126-1&ia=web https://duckduckgo.com/?t=ffab&q=+Ivermectin+meta-analysis&a...
jiofih 5y ago
Or it proves that meta-analyses are meaningless when you can pick the target studies at will.
loceng 5y ago
The issue I've seen with various studies who claim statistically insignificance when using Ivermectin is because they use too low of a dose and/or don't use it long enough (3 to 5 days instead of 14 days) and/or they don't start using it at first symptoms (in part I've read this can be because can take days for COVID positive tested person to enrol in a study hence giving the virus more time to replicate/take strong hold).
6nf 5y ago
Google results for Ivermectin is inorganic
isolli 5y ago
This article is a pre-print with severe mistakes (in particular they inverted the results for the treatment and control groups in one of the studies, you can't make this up). Read the comments. It's highly unlikely the piece will be published. Read this peer-reviewed and accepted meta-analysis instead [0]. Conclusion: low- to moderate-certainty evidence of a positive effect depending on the endpoint. Higher certainty would come from higher-powered studies. [0] https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009446 https://journals.plos.org/plosntds/article?id=10.1371/journa...

zanethomas 5y ago

compare to duckduckgo results https://duckduckgo.com/?t=ffab&q=+Ivermectin+meta-analysis&atb=v126-1&ia=web https://duckduckgo.com/?t=ffab&q=+Ivermectin+meta-analysis&a...

jiofih 5y ago

Or it proves that meta-analyses are meaningless when you can pick the target studies at will.

loceng 5y ago

The issue I've seen with various studies who claim statistically insignificance when using Ivermectin is because they use too low of a dose and/or don't use it long enough (3 to 5 days instead of 14 days) and/or they don't start using it at first symptoms (in part I've read this can be because can take days for COVID positive tested person to enrol in a study hence giving the virus more time to replicate/take strong hold).

6nf 5y ago

Google results for Ivermectin is inorganic

isolli 5y ago

This article is a pre-print with severe mistakes (in particular they inverted the results for the treatment and control groups in one of the studies, you can't make this up). Read the comments. It's highly unlikely the piece will be published. Read this peer-reviewed and accepted meta-analysis instead [0]. Conclusion: low- to moderate-certainty evidence of a positive effect depending on the endpoint. Higher certainty would come from higher-powered studies. [0] https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009446 https://journals.plos.org/plosntds/article?id=10.1371/journa...