5 ms·
But dose matters is the take home message. Several drugs have different overall effects at different doses.
by Engineering-MD 5y ago
But dose matters is the take home message. Several drugs have different overall effects at different doses.
- rantwasp 5y agoI would say that most drugs have different effects at different doses. It's usually not the drug that is the problems, it's the dosage. To answer the rapamycin question: the normal dose that is given in case of an organ transplant is 6mg on day one and after that 2mg per day. That makes for 14-18mg/week. For longevity what I've heard is 3-5mg once per week. Now take your normal OTC drug, let's say Tylenol and take 3-4 times the recommended dose. Liver injury or even liver failure follows.
- Engineering-MD 5y agoI was more meaning within the therapeutic window, but you are quite right of course.