The author makes a couple of arguments. Some like "we should increase the quality of our research by doing more pre-registration because we are sacrificing the

The author makes a couple of arguments. Some like "we should increase the quality of our research by doing more pre-registration because we are sacrificing these animals in the pursuit of science and when we do bad science we make the sacrifice for naught" yes 100%!!! But when he argues that there is poor translatability from rats to people (true) so therefore we should try doing more in vitro studies or going directly into humans. I think as bad as rat/mouse studies are in vitro studies have even worse translatability.