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This has me concerned that DHA could actually be harmful for non-cancerous cells as well while doing a water diet or a ketogenic diet. The lipid metabolism inh

This has me concerned that DHA could actually be harmful for non-cancerous cells as well while doing a water diet or a ketogenic diet. The lipid metabolism inhibitor was used to enhance the already present DHA toxicity mechanism for the cancerous cells, and the toxicity was provoked by the fact that metastasing cancerous cells place themselves in ketosis (=acidosis).

MrBuddyCasino 5y ago
This is what Ray Peat has been saying for years. He researches nutrition with a specific angle - does something inhibit metabolism or does it accelerate? His thesis is that nutrition should be optimized to make metabolism go as efficient as possible. I'm not sure how valid his ideas are, but it is definitely worth checking out. Whenever you see people warn about seed oils and PUFAs, they are usually basing their views on his research.
adrian_b 5y ago
It is very likely that all kinds of poly-unsaturated fatty acids, both the omega-3 and the omega-6, are harmful in too large quantities. Before being degraded easily like MUFA or saturated fatty acids, the PUFA must pass through various transformation reactions that can be performed by our body mainly in the liver and only with a limited rate. When the quantity of PUFA exceeds that which is needed for the maintenance of various cellular membranes by more than can be degraded in a given time, they accumulate and can be harmful. The problem, like for any other kind of food, is that it is extremely difficult to determine experimentally which are the minimum dose per day and the maximum dose per day outside which an omega-3 acid or any other substance becomes harmful instead of useful. The main difficulty is that those limits are not absolute, but they depend on the quantities of other substances eaten at the same time and on the kinds of activities that are performed. So it is not surprising that the results of various studies are contradictory. For omega-3, most studies that I have seen showed improvements up to 2-3 grams per day and no harmful effects that could appear in a short time up to a dose 2 or 3 times larger than that. While there is no doubt that you need both some EPA and some DHA, there is no certainty about which would be the right quantity of each per day. For example some studies have shown that for the brain and against some inflammatory conditions it is better to eat more DHA than EPA, other studies have shown that for the heart it is better to eat more EPA than DHA. It is impossible to know how much the results of such studies are influenced by whatever else the study subjects have eaten at the same time. Nevertheless, it is unlikely that the inferior limit and the superior limit for omega-3 consumption are very close. Therefore eating a few grams per day should be safe. I assume that for killing a tumor much higher doses are needed.
TurboHaskal 5y ago
Back in the day, like ten years ago or so it was very trendy for health gurus to promote high doses of fish oil supplementation (minimum 3g daily of combined EPA+DHA, ideally way more). You can still find posts from angry users in forums complaining about loss of libido, hypothyroidism and erectile dysfunction. I would stay away from it, but it might be worth it for vegetarians, pregnant and lactating women. Or if you eat the average (crap) western diet.
- wil421 5y ago
  I remember this trend. Some of my bodybuilder friends would be taking shots of olive oil and fish oil in the morning and night.

MrBuddyCasino 5y ago

This is what Ray Peat has been saying for years. He researches nutrition with a specific angle - does something inhibit metabolism or does it accelerate? His thesis is that nutrition should be optimized to make metabolism go as efficient as possible. I'm not sure how valid his ideas are, but it is definitely worth checking out. Whenever you see people warn about seed oils and PUFAs, they are usually basing their views on his research.

adrian_b 5y ago

It is very likely that all kinds of poly-unsaturated fatty acids, both the omega-3 and the omega-6, are harmful in too large quantities. Before being degraded easily like MUFA or saturated fatty acids, the PUFA must pass through various transformation reactions that can be performed by our body mainly in the liver and only with a limited rate. When the quantity of PUFA exceeds that which is needed for the maintenance of various cellular membranes by more than can be degraded in a given time, they accumulate and can be harmful. The problem, like for any other kind of food, is that it is extremely difficult to determine experimentally which are the minimum dose per day and the maximum dose per day outside which an omega-3 acid or any other substance becomes harmful instead of useful. The main difficulty is that those limits are not absolute, but they depend on the quantities of other substances eaten at the same time and on the kinds of activities that are performed. So it is not surprising that the results of various studies are contradictory. For omega-3, most studies that I have seen showed improvements up to 2-3 grams per day and no harmful effects that could appear in a short time up to a dose 2 or 3 times larger than that. While there is no doubt that you need both some EPA and some DHA, there is no certainty about which would be the right quantity of each per day. For example some studies have shown that for the brain and against some inflammatory conditions it is better to eat more DHA than EPA, other studies have shown that for the heart it is better to eat more EPA than DHA. It is impossible to know how much the results of such studies are influenced by whatever else the study subjects have eaten at the same time. Nevertheless, it is unlikely that the inferior limit and the superior limit for omega-3 consumption are very close. Therefore eating a few grams per day should be safe. I assume that for killing a tumor much higher doses are needed.

TurboHaskal 5y ago

Back in the day, like ten years ago or so it was very trendy for health gurus to promote high doses of fish oil supplementation (minimum 3g daily of combined EPA+DHA, ideally way more). You can still find posts from angry users in forums complaining about loss of libido, hypothyroidism and erectile dysfunction. I would stay away from it, but it might be worth it for vegetarians, pregnant and lactating women. Or if you eat the average (crap) western diet.

wil421 5y ago
I remember this trend. Some of my bodybuilder friends would be taking shots of olive oil and fish oil in the morning and night.