There's a lot of unresolved debate in the philosophy of mind about how the mind might come about from the brain. Not all hypotheses assert substrate-dependant

There's a lot of unresolved debate in the philosophy of mind about how the mind might come about from the brain. Not all hypotheses assert substrate-dependant epiphenomenalism, which is what you seem to be suggesting. So our current understanding is merely that we have little clue whether it's possible. I lean towards the idea that it's possible and view the burden of proof as being on your shoulders to show why wetware as a substrate is necessary.