5 ms·

Covid Spike Protein Elicits Signaling in Host Cells: Implications for Vaccines

24 points by AndrewBissell 5y ago

dmitrygr 5y ago
Good that we know this AFTER most already got vaccinated. /S
bijant 5y ago
The Article seems to be from January.
- Grim-444 5y ago
  What are you implying, that science published five months ago is invalid?
  - bijant 5y ago
    Not at all. But since the time this was published many people have been vaccinated and we have a lot of data that the researchers didn’t have at the time of publication. The Speculation in the article, while totally valid at the time, should be replaced by a comprehensive analysis of the available data.
    - AndrewBissell 5y ago
      I would think the recent concerns around myocarditis indicate there may be some reason to take the article's speculation about potential cardiac effects seriously.
    - T-A 5y ago
      The pulmonary hypertension they worry about is hard to detect and takes a few years to kill you. A few months may not be enough for it to have become noticeable.
rolph 5y ago
free floating spike in vitro cultured human cells developed pathological state. when a spike protien is expressed as an insertion into the cytoplasmic membrane there is very limited mobility, and less potential to approach ACE2 with appropriate orientation and energy for receptor ligand-interaction to occur, this would result in somewhat less interaction of the spike with the rennin angiotensin system[RAS]. a concern would be the possible development of abberant or deletion type spike protiens translated from undesirerable spike-mRNA species, the scenario of most concern would be a spike protien with malformed or deleted transmembrane domains, thus allowing a speudo spike protien to move freely outside the host cell. this doesnt indicate that there is an unconceived problem, this publication is recognizing that perturbations of the RAS are highly consequential; a major part of covid pathology; and a hidden gotcha, should vaccine development ever become cavalier regarding RAS signaling and spike based agents
londons_explore 5y ago
Thought experiment: Imagine this spike protein, either from COVID or a vaccine causes a chain of events causing ones children to be infertile. There are various environmental things that can cause offspring to be infertile, so the scenario isn't totally unreasonable. We probably wouldn't figure that out for ~20 years. By that point, probably 95% of earth's population will have been vaccinated or exposed. For a newborn to be fertile, they need two non-affected parents. So the chances of that might be 0.05*0.05 = 0.0025. What would society look like with a generation where 99.75% of people are infertile? Luckily the chances of my hypothetical happening are nearly nil... But it's still scary!
- sschueller 5y ago
  It is more likely that we become infertile from the chemicals and pesticides we get in contact with every day. https://news.harvard.edu/gazette/story/2015/03/pesticides-result-in-lower-sperm-counts/ https://news.harvard.edu/gazette/story/2015/03/pesticides-re... https://www.hormone.org/your-health-and-hormones/endocrine-disrupting-chemicals-edcs https://www.hormone.org/your-health-and-hormones/endocrine-d...
- deleted 5y ago
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- deleted 5y ago
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- aazaa 5y ago
  > What would society look like with a generation where 99.75% of people are infertile? I can think of at least one fictionalized exploration of that idea. A couple of books and a TV series were made.
  - T-A 5y ago
    https://en.wikipedia.org/wiki/The_Children_of_Men https://en.wikipedia.org/wiki/The_Children_of_Men Set in 2021, BTW.
    - 5y ago
Hypergraphe 5y ago
Thanks now I have anxiety.
tinus_hn 5y ago
If this causes problems, the disease causes the same problems.
fancythat 5y ago
Contrarian view: https://respectfulinsolence.com/2021/04/29/no-theres-no-good-evidence-that-spike-protein-from-covid-19-vaccine-injures-the-lungs/ https://respectfulinsolence.com/2021/04/29/no-theres-no-good...

24 points by AndrewBissell 5y ago

dmitrygr 5y ago

Good that we know this AFTER most already got vaccinated. /S

bijant 5y ago

The Article seems to be from January.

Grim-444 5y ago
What are you implying, that science published five months ago is invalid?
- bijant 5y ago
  Not at all. But since the time this was published many people have been vaccinated and we have a lot of data that the researchers didn’t have at the time of publication. The Speculation in the article, while totally valid at the time, should be replaced by a comprehensive analysis of the available data.
  - AndrewBissell 5y ago
    I would think the recent concerns around myocarditis indicate there may be some reason to take the article's speculation about potential cardiac effects seriously.
  - T-A 5y ago
    The pulmonary hypertension they worry about is hard to detect and takes a few years to kill you. A few months may not be enough for it to have become noticeable.

rolph 5y ago

free floating spike in vitro cultured human cells developed pathological state. when a spike protien is expressed as an insertion into the cytoplasmic membrane there is very limited mobility, and less potential to approach ACE2 with appropriate orientation and energy for receptor ligand-interaction to occur, this would result in somewhat less interaction of the spike with the rennin angiotensin system[RAS]. a concern would be the possible development of abberant or deletion type spike protiens translated from undesirerable spike-mRNA species, the scenario of most concern would be a spike protien with malformed or deleted transmembrane domains, thus allowing a speudo spike protien to move freely outside the host cell. this doesnt indicate that there is an unconceived problem, this publication is recognizing that perturbations of the RAS are highly consequential; a major part of covid pathology; and a hidden gotcha, should vaccine development ever become cavalier regarding RAS signaling and spike based agents

londons_explore 5y ago

Thought experiment: Imagine this spike protein, either from COVID or a vaccine causes a chain of events causing ones children to be infertile. There are various environmental things that can cause offspring to be infertile, so the scenario isn't totally unreasonable. We probably wouldn't figure that out for ~20 years. By that point, probably 95% of earth's population will have been vaccinated or exposed. For a newborn to be fertile, they need two non-affected parents. So the chances of that might be 0.05*0.05 = 0.0025. What would society look like with a generation where 99.75% of people are infertile? Luckily the chances of my hypothetical happening are nearly nil... But it's still scary!

sschueller 5y ago
It is more likely that we become infertile from the chemicals and pesticides we get in contact with every day. https://news.harvard.edu/gazette/story/2015/03/pesticides-result-in-lower-sperm-counts/ https://news.harvard.edu/gazette/story/2015/03/pesticides-re... https://www.hormone.org/your-health-and-hormones/endocrine-disrupting-chemicals-edcs https://www.hormone.org/your-health-and-hormones/endocrine-d...
deleted 5y ago
[deleted]
deleted 5y ago
[deleted]
aazaa 5y ago
> What would society look like with a generation where 99.75% of people are infertile? I can think of at least one fictionalized exploration of that idea. A couple of books and a TV series were made.
- T-A 5y ago
  https://en.wikipedia.org/wiki/The_Children_of_Men https://en.wikipedia.org/wiki/The_Children_of_Men Set in 2021, BTW.
  - 5y ago

Hypergraphe 5y ago

Thanks now I have anxiety.

tinus_hn 5y ago

If this causes problems, the disease causes the same problems.

fancythat 5y ago

Contrarian view: https://respectfulinsolence.com/2021/04/29/no-theres-no-good-evidence-that-spike-protein-from-covid-19-vaccine-injures-the-lungs/ https://respectfulinsolence.com/2021/04/29/no-theres-no-good...